Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8895979 | 0.82 | METAP2 (0.45) | METAP2 | |
| SCHEMBL9386500 | 0.79 | SLC1A3 (0.35) | — | |
| SCHEMBL8201992 | 0.71 | METAP2 (0.42) | METAP2 | |
| SCHEMBL8282730 | 0.71 | METAP2 (0.42) | METAP2 | |
| SCHEMBL7446286 | 0.69 | LTB4R (0.33) | — | |
| SCHEMBL16732255 | 0.69 | METAP2 (0.41) | METAP2 | |
| SCHEMBL16732152 | 0.68 | METAP2 (0.43) | METAP2 | |
| SCHEMBL6882316 | 0.67 | HPGD (0.41) | — | |
| SCHEMBL6882320 | 0.67 | HPGD (0.41) | — | |
| SCHEMBL6882324 | 0.67 | HPGD (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5164388-A | Hypotensive agents, treatment of congestive heart failure | ABBOTT LABORATORIES (US) | 1992-11-17 | — | — | US | disclosed |
| EP-0439556-A4 | HETEROCYCLIC PEPTIDE RENIN INHIBITORS | — | 1991-10-30 | — | — | EP | disclosed |
| EP-0439556-A1 | HETEROCYCLIC PEPTIDE RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1991-08-07 | — | — | EP | disclosed |
| WO-1990004917-A1 | HETEROCYCLIC PEPTIDE RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1990-05-17 | — | — | WO | disclosed |
| EP-0365992-A1 | Heterocyclic peptide renin inhibitors | ABBOTT LABORATORIES (US) | 1990-05-02 | — | — | EP | disclosed |