SCHEMBL8896068

SCHEMBL8896068

CCOC(=O)[CH]C(=O)c1ccccc1

nearest known ligand 0.60

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.60
KMT2A Q03164 4/20 0.49
MEN1 O00255 3/20 0.49
RAB9A P51151 3/20 0.49
MAPK1 P28482 2/20 0.49
NPC1 O15118 2/20 0.49
ALDH1A1 P00352 2/20 0.49
CASP3 P42574 1/20 0.48
SENP8 Q96LD8 1/20 0.48
SENP7 Q9BQF6 1/20 0.48
SENP6 Q9GZR1 1/20 0.48
AKT1 P31749 1/20 0.46
LMNA P02545 1/20 0.46
PTGS2 P35354 1/20 0.46
TSHR P16473 1/20 0.46
TDP1 Q9NUW8 1/20 0.45
NPSR1 Q6W5P4 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3372572 0.84 MAPT (0.72) MAPTKMT2AMEN1RAB9AMAPK1
SCHEMBL3371348 0.84 MAPT (0.72) MAPTKMT2AMEN1RAB9AMAPK1
SCHEMBL9751109 0.84 MAPT (0.72) MAPTKMT2AMEN1RAB9AMAPK1
SCHEMBL28908344 0.82 MAOB (0.49) MAPTKMT2AMEN1RAB9AMAPK1
SCHEMBL8998065 0.82 MAPT (0.54) MAPTKMT2AMEN1RAB9ANPC1
SCHEMBL10544461 0.79 TSHR (0.54) MAPTKMT2AMEN1RAB9AMAPK1
Diethyl Maleate SCHEMBL11324124 0.78 MAPT (0.60) MAPTKMT2AMEN1RAB9ANPC1
SCHEMBL15079085 0.78 MAPT (0.53) MAPTKMT2AMEN1RAB9AMAPK1
SCHEMBL14186862 0.78 MAPT (0.53) MAPTKMT2AMEN1RAB9ANPC1
SCHEMBL1070286 0.78 MEN1 (0.53) MAPTKMT2AMEN1RAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5670563-A ORGANOTIN COMPOUND, PHOSPHORUS COMPOUND CIBA-SPECIALTY CHEMICALS CORPORATION (US) 1997-09-23 US disclosed
EP-0433024-B1 Colour recording medium containing leuco dye FUJI PHOTO FILM CO LTD (JP) 1994-09-21 EP disclosed
EP-0304613-B1 BENZOPYRAN DERIVATIVES BASF Aktiengesellschaft (DE) 1991-06-26 EP disclosed
EP-0433024-A1 Colour recording medium containing leuco dye FUJI PHOTO FILM CO., LTD. (JP) 1991-06-19 EP disclosed
US-4966983-A PRESSURE OR HEAT SENSITIVE ELEMENTS BASF AKTIENGESELLSCHAFT (DE) 1990-10-30 US disclosed
US-4958021-A PRESSURE AND HEAT SENSITIVE RECORDING MATERIALS BASF AKTIENGESELLSCHAFT (DE) 1990-09-18 US disclosed
US-4841050-A Carbazole containing benzopyrans BASF AKTIENGESELLSCHAFT (DE) 1989-06-20 US disclosed
EP-0236973-B1 BENZOPYRANES AND THEIR USE IN A RECORDING SYSTEM BASF Aktiengesellschaft (DE) 1989-06-14 EP disclosed
EP-0304613-A1 Benzopyran derivatives BASF Aktiengesellschaft (DE) 1989-03-01 EP disclosed
US-4022773-A 7-ACYLAMINO-3-SUBSTITUTED-3-CEPHEM-4-CARBOXYLIC ACIDS, 1-OXIDES ISHIMARU TOSHIYASU 1977-05-10 US disclosed