SCHEMBL8896265

SCHEMBL8896265

COC(=O)CC1C(=O)N(CCc2ccccc2)Cc2cc(-c3ccc(C(=N)N)cc3)ccc2N1NC=O

nearest known ligand 0.45

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ITGB3 P05106 18/20 0.45
ITGA2B P08514 18/20 0.45
ITGAV P06756 2/20 0.45
F2 P00734 2/20 0.37
F10 P00742 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8897233 0.90 ITGB3 (0.42) ITGB3ITGA2BITGAVF2F10
SCHEMBL8401186 0.83 ITGB3 (0.45) ITGB3ITGA2BITGAVF2
SCHEMBL8398958 0.73 ITGB3 (0.57) ITGB3ITGA2BITGAV
SCHEMBL7402539 0.73 ITGB3 (0.59) ITGB3ITGA2BITGAVF2F10
SCHEMBL7595687 0.71 ITGB3 (0.69) ITGB3ITGA2BITGAVF2F10
SCHEMBL7395726 0.71 ITGB3 (0.69) ITGB3ITGA2BITGAVF2F10
SCHEMBL7397591 0.71 ITGB3 (0.68) ITGB3ITGA2BITGAV
SCHEMBL7399596 0.71 ITGB3 (0.68) ITGB3ITGA2BITGAV
SCHEMBL7442838 0.70 ITGB3 (0.54) ITGB3ITGA2BITGAV
SCHEMBL7442820 0.70 ITGB3 (0.54) ITGB3ITGA2BITGAV

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5693636-A Bicyclic fibrinogen antagonists SMITHKLINE BEECHAM CORPORATION (US) 1997-12-02 US disclosed