Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.65 |
| ▸ | DRD4 | P21917 | 1/20 | 0.65 |
| ▸ | HTR2A | P28223 | 1/20 | 0.65 |
| ▸ | DRD3 | P35462 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29462918 | 0.83 | DRD2 (0.79) | DRD2DRD4HTR2ADRD3MEN1 | |
| Hydrochloric Acid SCHEMBL30050104 | 0.82 | DRD2 (0.76) | DRD2DRD4HTR2ADRD3MEN1 | |
| SCHEMBL5108598 | 0.81 | OPRL1 (0.52) | — | |
| SCHEMBL318863 | 0.79 | OPRL1 (0.49) | — | |
| Mespiperone SCHEMBL1901596 | 0.79 | DRD2 (1.00) | DRD2DRD4HTR2ADRD3MEN1 | |
| SCHEMBL30405289 | 0.79 | DRD2 (0.74) | DRD2DRD4HTR2ADRD3MEN1 | |
| Mespiperone SCHEMBL10733631 | 0.78 | DRD2 (0.98) | DRD2DRD4HTR2ADRD3MEN1 | |
| SCHEMBL319140 | 0.78 | BDKRB2 (0.49) | MEN1CYP3A4CYP2D6KMT2A | |
| SCHEMBL29430174 | 0.77 | MEN1 (1.00) | DRD2DRD4HTR2ADRD3MEN1 | |
| SCHEMBL13073119 | 0.77 | MEN1 (1.00) | DRD2DRD4HTR2ADRD3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5703088-A | Topical application of spiperone or derivatives thereof for treatment of pathological conditions associated with immune responses | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) | 1997-12-30 | — | — | US | disclosed |
| US-5693645-A | TOPICALLY OR SYSTEMICALLY ADMINISTERING TO THE MAMMAL; USEFUL FOR TREATING INFLAMMATORY BOWL DISEASE | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) | 1997-12-02 | — | — | US | disclosed |