Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | TERT | O14746 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9423285 | 0.97 | CHEK1 (0.45) | MAPTNPC1RAB9AALDH1A1LMNA | |
| SCHEMBL3160291 | 0.81 | ALDH1A1 (0.55) | MAPTNPC1RAB9AALDH1A1LMNA | |
| SCHEMBL9849269 | 0.78 | ELANE (0.53) | MAPTNPC1RAB9AALDH1A1LMNA | |
| SCHEMBL6254969 | 0.78 | NPC1 (0.63) | MAPTNPC1RAB9AALDH1A1LMNA | |
| SCHEMBL9423354 | 0.78 | CHEK1 (0.65) | MAPTNPC1RAB9AALDH1A1LMNA | |
| SCHEMBL29117498 | 0.76 | ELANE (0.55) | MAPTNPC1RAB9AALDH1A1LMNA | |
| SCHEMBL30021053 | 0.76 | NPC1 (0.66) | MAPTNPC1RAB9AALDH1A1LMNA | |
| SCHEMBL41511 | 0.76 | NPC1 (0.66) | MAPTNPC1RAB9AALDH1A1LMNA | |
| SCHEMBL8893419 | 0.76 | BCL2 (0.58) | MAPTNPC1RAB9AALDH1A1LMNA | |
| Ammonia Solution, Strong SCHEMBL27784024 | 0.74 | NPC1 (0.63) | MAPTNPC1RAB9AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997004770-A1 | 2-(FLUORENONYL)-CARBAPENEMS, COMPOSITIONS AND METHODS OF USE | MERCK & CO., INC. (US) | 1997-02-13 | — | — | WO | disclosed |
| US-5541177-A | BACTERICIDES | MERCK & CO., INC. (US) | 1996-07-30 | — | — | US | disclosed |
| US-5534507-A | BACTERIA INFECTIONS | MERCK & CO., INC. (US) | 1996-07-09 | — | — | US | disclosed |
| US-5455239-A | Cephalosporin antibiotics | MERCK & CO. INC. (US) | 1995-10-03 | — | — | US | disclosed |
| US-5451579-A | 1-β-methyl-carbapenem, compositions containing same and methods of use | MERCK & CO., INC. (US) | 1995-09-19 | — | — | US | disclosed |
| WO-1995021841-A1 | 1-β-METHYL-CARBAPENEM, COMPOSITIONS CONTAINING SAME AND METHODS OF USE | MERCK & CO., INC. (US) | 1995-08-17 | — | — | WO | disclosed |
| US-5356889-A | Carbapenicillins | MERCK & CO., INC. (US) | 1994-10-18 | — | — | US | disclosed |
| US-5144028-A | Antibiotics | MERCK & CO., INC. (US) | 1992-09-01 | — | — | US | disclosed |
| EP-0472306-A1 | 2-(9-fluorenonyl)-carbapenem antibacterial agents | MERCK & CO. INC. (US) | 1992-02-26 | — | — | EP | disclosed |
| EP-0469844-A1 | 2-(9-fluorenonyl)-carbapenem | MERCK & CO. INC. (US) | 1992-02-05 | — | — | EP | disclosed |
| US-5034384-A | Bactericides, antibiotics for resistant bacteria | MERCK & CO., INC. (US) | 1991-07-23 | — | — | US | disclosed |
| US-5025007-A | 2-(9-fluorenonyl)-carbapenem antibacterial agents | MERCK & CO., INC. (US) | 1991-06-18 | — | — | US | disclosed |