Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.31 |
| ▸ | TDP2 | O95551 | 1/20 | 0.30 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | PNMT | P11086 | 1/20 | 0.30 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.30 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8563483 | 0.72 | RXRA (0.32) | — | |
| SCHEMBL6814457 | 0.72 | PBRM1 (0.39) | PDE4BPBRM1TDP2MEN1KMT2A | |
| SCHEMBL6878453 | 0.69 | ESR2 (0.43) | PDE4BPBRM1TDP2MEN1KMT2A | |
| SCHEMBL24806899 | 0.66 | KDM1A (0.37) | PDE4BADRA2APNMTADRA2BADRA2C | |
| SCHEMBL24806881 | 0.66 | KDM1A (0.37) | PDE4BADRA2APNMTADRA2BADRA2C | |
| SCHEMBL6876533 | 0.66 | PDE4B (0.34) | PDE4BPBRM1TDP2MEN1KMT2A | |
| SCHEMBL7880635 | 0.64 | PDE4B (0.46) | PDE4BTDP2MEN1KMT2A | |
| SCHEMBL484599 | 0.64 | PDE4B (0.46) | PDE4BPBRM1TDP2MEN1KMT2A | |
| SCHEMBL6280501 | 0.63 | BACE1 (0.33) | PDE4BPBRM1TDP2ADRA2APNMT | |
| SCHEMBL8026081 | 0.62 | ALDH1A1 (0.38) | ADRA2APNMTADRA2BADRA2CMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997048672-A2 | SUBSTITUTED TETRAHYDRONAPHTHALENE AND DIHYDRONAPHTHALENE DERIVATIVES HAVING RETINOID AND/OR RETINOID ANTAGONIST-LIKE BIOLOGICAL ACTIVITY | ALLERGAN SALES, INC. (US) | 1997-12-24 | — | — | WO | disclosed |