SCHEMBL8897103

SCHEMBL8897103

O=C(O)c1cccc(OC(=O)c2ccccc2)c1

nearest known ligand 0.67

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
AKR1C3 P42330 1/20 0.67
KMT2A Q03164 8/20 0.62
MAPT P10636 2/20 0.62
TDP1 Q9NUW8 2/20 0.62
MEN1 O00255 1/20 0.62
ALDH1A1 P00352 1/20 0.59
NR4A2 P43354 1/20 0.57
ESR1 P03372 1/20 0.54
ESR2 Q92731 1/20 0.54
PARP10 Q53GL7 1/20 0.53
NSD2 O96028 1/20 0.53
KMO O15229 2/20 0.51
L3MBTL1 Q9Y468 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9356640 0.98 AKR1C3 (0.65) AKR1C3KMT2AMAPTTDP1MEN1
SCHEMBL11270798 0.96 AKR1C3 (0.61) AKR1C3KMT2AMAPTTDP1MEN1
SCHEMBL11280339 0.94 AKR1C3 (0.59) AKR1C3KMT2AMAPTTDP1MEN1
SCHEMBL11196204 0.92 AKR1C3 (0.61) AKR1C3KMT2AMAPTTDP1MEN1
Isophthalic Acid SCHEMBL2889737 0.91 PARP10 (0.61) AKR1C3KMT2AMAPTTDP1MEN1
SCHEMBL1785471 0.90 KMT2A (0.69) KMT2AMAPTTDP1MEN1ALDH1A1
SCHEMBL8405844 0.90 ESR1 (0.56) AKR1C3KMT2AMAPTTDP1MEN1
SCHEMBL18965052 0.90 KMO (0.62) AKR1C3KMT2AMAPTTDP1MEN1
SCHEMBL28467374 0.89 AKR1C3 (0.62) AKR1C3KMT2AMAPTTDP1MEN1
SCHEMBL23064097 0.89 KMT2A (0.62) AKR1C3KMT2AMAPTTDP1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210170033-A1 NOVEL CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN SANOFI (FR) 2021-06-10 US disclosed
CN-106674001-B A kind of synthetic method of m-methoxybenzoic acid 三峡大学 2019-09-24 CN disclosed
CN-100489027-C Flame-retardant epoxy resin composition and phosphorus-containing compound CHANGCHUN ARTIFICIAL RESIN FAC (CN) 2009-05-20 CN disclosed
CN-1580120-A Flame-retardant epoxy resin composition and phosphorus-containing compound CHANGCHUN ARTIFICIAL RESIN FAC (CN) 2005-02-16 CN disclosed
CN-1580108-A Phosphorus-containing compound ARTIFICIAL RESIN FACTORY CO LT (CN) 2005-02-16 CN disclosed
US-5683682-A Derivatives of aromatic benzoates as inhibitors of esterase-producing micro-organisms ROBERTET S.A. (FR) 1997-11-04 US disclosed
EP-0606197-B1 USE OF AROMATIC BENZOATES AS PERSONAL DEODORANTS ROBERTET SA (FR) 1996-01-31 EP disclosed
EP-0606197-A1 DERIVATIVES OF AROMATIC BENZOATES AS INHIBITORS OF ESTERASE-PRODUCING MICRO-ORGANISMS. ROBERTET SA (FR) 1994-07-20 EP disclosed
WO-1991007165-A1 DERIVATIVES OF AROMATIC BENZOATES AS INHIBITORS OF ESTERASE-PRODUCING MICRO-ORGANISMS ROBERTET S.A. (FR) 1991-05-30 WO disclosed
US-4006239-A Benzoic acid amides for mycobacterium infections BAYER AKTIENGESELLSCHAFT (DT) 1977-02-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210170033-A1 NOVEL CONJUGATES OF A PHARMACEUTICAL AGENT AND A MOIETY CAPABLE OF BINDING TO A GLUCOSE SENSING PROTEIN GPR119, SLC2A8, SLC2A4 AKR1C3 1611/4885KMT2A 4555/4885MAPT 3481/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.