SCHEMBL8897425

SCHEMBL8897425

CSc1ccc(C(=O)C(C)(Cc2ccc(C(=O)c3ccccc3)cc2)N(C)C)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.41
MEN1 O00255 2/20 0.41
TAS2R14 Q9NYV8 1/20 0.41
RAB9A P51151 2/20 0.40
HPGD P15428 2/20 0.40
NPC1 O15118 1/20 0.40
EPHX2 P34913 1/20 0.40
NR1H4 Q96RI1 1/20 0.40
PPARG P37231 4/20 0.38
PPARD Q03181 2/20 0.38
PPARA Q07869 2/20 0.38
ALDH1A1 P00352 3/20 0.38
ACHE P22303 2/20 0.38
TSHR P16473 1/20 0.38
MAPK1 P28482 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
LMNA P02545 1/20 0.37
AKR1C3 P42330 1/20 0.37
AKR1C2 P52895 1/20 0.37
AKR1C1 Q04828 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8898468 0.95 KMT2A (0.45) KMT2AMEN1TAS2R14RAB9ANPC1
SCHEMBL8898243 0.91 EPHX2 (0.46) KMT2AMEN1TAS2R14RAB9ANPC1
SCHEMBL3322033 0.91 HPGD (0.47) RAB9AHPGDNPC1PPARGPPARA
SCHEMBL8897900 0.88 HPGD (0.47) RAB9AHPGDNPC1PPARGPPARA
SCHEMBL8961749 0.88 ALDH1A1 (0.42) KMT2AMEN1TAS2R14RAB9AHPGD
SCHEMBL8898365 0.86 EPHX2 (0.42) KMT2AMEN1TAS2R14RAB9AHPGD
SCHEMBL8897095 0.85 AKR1C3 (0.42) KMT2AMEN1RAB9AHPGDNPC1
SCHEMBL8898784 0.85 EPHX2 (0.41) KMT2AMEN1TAS2R14RAB9AHPGD
SCHEMBL8899259 0.85 LMNA (0.45) KMT2AMEN1TAS2R14EPHX2NR1H4
SCHEMBL8898303 0.82 MAPT (0.42) KMT2AMEN1RAB9ANPC1EPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5629356-A PHOTOCURABLE COMPOSITION CONTAINING ETHYLENICALLY UNSATURATED PHOTOPOLYMERIZABLE COMPOUND AND THE AMINOACETOPHENONE CIBA GEIGY CORPORATION (US) 1997-05-13 US disclosed
US-5534629-A PHOTOPOLYMERIZATION OF PIGMENTED SYSTEMS, INKS CIBA-GEIGY CORPORATION (US) 1996-07-09 US disclosed
EP-0284561-B1 ALPHA-AMINOACETOPHENONES AS PHOTO INITIATORS CIBA-GEIGY AG (CH) 1993-05-12 EP disclosed
US-5077402-A For photocuring pigmented systems; printing inks, lacquers CIBA-GEIGY CORPORATION (US) 1991-12-31 US disclosed
EP-0284561-A2 Alpha-aminoacetophenones as photo initiators CIBA-GEIGY AG (CH) 1988-09-28 EP disclosed