Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.42 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 known ✓ | P08173 | 1/20 | 0.42 |
| ▸ | CHRM5 known ✓ | P08912 | 1/20 | 0.42 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8560813 | 1.00 | KMT2A (0.46) | KMT2AMEN1USP2HSD17B10SMN1; SMN2 | |
| Bromide SCHEMBL26663611 | 0.88 | BTK (0.46) | KMT2AMEN1SMN1; SMN2POLBKDM4E | |
| Bromide SCHEMBL8897942 | 0.81 | ALDH1A1 (0.47) | KMT2AMEN1SMN1; SMN2POLBKDM4E | |
| Bromide SCHEMBL8568645 | 0.81 | ALDH1A1 (0.47) | KMT2AMEN1SMN1; SMN2POLBKDM4E | |
| Bromide SCHEMBL8567147 | 0.81 | SIGMAR1 (0.47) | KMT2AMEN1 | |
| Bromide SCHEMBL8899316 | 0.81 | SIGMAR1 (0.47) | KMT2AMEN1 | |
| Bromide SCHEMBL8563399 | 0.79 | HDAC1 (0.43) | KMT2AMEN1POLBCYP2D6HDAC1 | |
| Bromide SCHEMBL8563395 | 0.79 | HDAC1 (0.43) | KMT2AMEN1POLBCYP2D6HDAC1 | |
| Bromide SCHEMBL8901003 | 0.78 | SIGMAR1 (0.50) | KMT2AMEN1KDM4ECHRM3CHRM2 | |
| Bromide SCHEMBL8563260 | 0.78 | SIGMAR1 (0.50) | KMT2AMEN1KDM4ECHRM3CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0761673-A1 | Cephalosporin derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-12 | — | — | EP | disclosed |