SCHEMBL8898516

SCHEMBL8898516

COc1ccc(-c2ccccc2)c(N)c1OC

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.45
RAB9A P51151 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
FYN P06241 1/20 0.44
ALOX5AP P20292 1/20 0.43
FEN1 P39748 1/20 0.43
ALDH1A1 P00352 2/20 0.43
POLB P06746 1/20 0.43
IDO1 P14902 2/20 0.42
TDO2 P48775 1/20 0.42
HDAC4 P56524 1/20 0.41
HDAC2 Q92769 1/20 0.41
HDAC8 Q9BY41 1/20 0.41
ACHE P22303 1/20 0.41
ADRA2B P18089 1/20 0.41
PTGS1 P23219 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
PDE4B Q07343 2/20 0.40
PDE4A P27815 1/20 0.40
PDE4C Q08493 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31607696 0.85 CHEK1 (0.49) SMN1; SMN2FYNALDH1A1TDP1
SCHEMBL13724254 0.85 ALOX5AP (0.47) NPC1RAB9ASMN1; SMN2FYNALOX5AP
SCHEMBL28929369 0.85 ALDH1A1 (0.43) NPC1RAB9ASMN1; SMN2FYNALOX5AP
SCHEMBL7205617 0.83 ALOX5AP (0.44) SMN1; SMN2FYNALOX5APFEN1ALDH1A1
SCHEMBL31607692 0.83 FYN (0.53) FYNALDH1A1
SCHEMBL31607664 0.83 FYN (0.53) FYNALDH1A1
SCHEMBL29788008 0.82 HDAC4 (0.53) NPC1RAB9ASMN1; SMN2ALDH1A1POLB
SCHEMBL4579619 0.82 HDAC4 (0.53) NPC1RAB9ASMN1; SMN2ALDH1A1POLB
SCHEMBL31607632 0.80 ALDH1A1 (0.48) NPC1RAB9ASMN1; SMN2ALDH1A1POLB
SCHEMBL13732796 0.80 FYN (0.50) FYNALDH1A1ACHEPDE4BPDE4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117024352-A Novel inhibitors 维沃里翁治疗股份有限公司 2023-11-10 CN disclosed
CN-110719910-B Novel inhibitors 维沃里翁治疗股份有限公司 2023-07-21 CN disclosed
CN-110719910-A Novel inhibitors 前体生物药物股份公司 2020-01-21 CN disclosed
CN-102645877-B Imaging device and formation method FUJI XEROX CORP. (JP) 2016-05-04 CN disclosed
CN-100378579-C Electronic photographic photoreceptor and mfg. method, processing card cassette and electronic photographic device FUJI XEROX CO LTD (JP) 2008-04-02 CN disclosed
CN-1412624-A Electronic photographic photoreceptor and mfg. method, processing card cassette and electronic photographic device FUJI XEROX CO LTD (JP) 2003-04-23 CN disclosed
EP-0671928-A4 SYNTHESIS OF N-SUBSTITUTED OLIGOMERS. CHIRON CORP (US) 1997-04-23 EP disclosed
EP-0671928-A1 SYNTHESIS OF N-SUBSTITUTED OLIGOMERS CHIRON CORPORATION (US) 1995-09-20 EP disclosed
WO-1994006451-A1 SYNTHESIS OF N-SUBSTITUTED OLIGOMERS CHIRON CORPORATION (US) 1994-03-31 WO disclosed