Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8898621 | 1.00 | MAPT (0.41) | MAPTALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL8900342 | 0.88 | HSP90AA1 (0.41) | MAPTALDH1A1HPGDGAAALOX15 | |
| SCHEMBL8900347 | 0.88 | HSP90AA1 (0.41) | MAPTALDH1A1HPGDGAAALOX15 | |
| SCHEMBL8899541 | 0.84 | MKNK1 (0.42) | MAPTALDH1A1KDM4ERAB9ARECQL | |
| SCHEMBL8899549 | 0.84 | MKNK1 (0.42) | MAPTALDH1A1KDM4ERAB9ARECQL | |
| SCHEMBL8898734 | 0.71 | PTGS2 (0.36) | MAPTALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL8898721 | 0.71 | PTGS2 (0.36) | MAPTALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL8900106 | 0.69 | ALDH1A1 (0.32) | MAPTALDH1A1KDM4EGAAKMT2A | |
| SCHEMBL8900098 | 0.69 | ALDH1A1 (0.32) | MAPTALDH1A1KDM4EGAAKMT2A | |
| SCHEMBL398186 | 0.67 | HDAC4 (0.58) | MAPTALDH1A1KDM4ERECQLHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808309-A1 | IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS S-ADENOSYLMETHIONINE DECARBOXYLASE (=SAMDC) INHIBITORS | Novartis AG (CH) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996022979-A1 | IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS S-ADENOSYLMETHIONINE DECARBOXYLASE (=SAMDC) INHIBITORS | NOVARTIS AG (CH) | 1996-08-01 | — | — | WO | disclosed |