Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | ATP4A | P20648 | 2/20 | 0.38 |
| ▸ | ATP4B | P51164 | 2/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8900347 | 1.00 | HSP90AA1 (0.41) | HSP90AA1HSP90AB1ALDH1A1GAAMETAP2 | |
| SCHEMBL8898621 | 0.88 | MAPT (0.41) | ALDH1A1GAAHSD17B10MAPTHPGD | |
| SCHEMBL8898613 | 0.88 | MAPT (0.41) | ALDH1A1GAAHSD17B10MAPTHPGD | |
| SCHEMBL8899549 | 0.80 | MKNK1 (0.42) | ALDH1A1GAAMAPTHPGDATP4A | |
| SCHEMBL8899541 | 0.80 | MKNK1 (0.42) | ALDH1A1GAAMAPTHPGDATP4A | |
| SCHEMBL8898721 | 0.78 | PTGS2 (0.36) | ALDH1A1GAAMAPTHPGDADORA2A | |
| SCHEMBL8898734 | 0.78 | PTGS2 (0.36) | ALDH1A1GAAMAPTHPGDADORA2A | |
| SCHEMBL1408091 | 0.74 | HSP90AA1 (0.53) | HSP90AA1HSP90AB1ALDH1A1GAAMETAP2 | |
| SCHEMBL8900106 | 0.73 | ALDH1A1 (0.32) | ALDH1A1GAAHSD17B10MAPTALOX15 | |
| SCHEMBL8900098 | 0.73 | ALDH1A1 (0.32) | ALDH1A1GAAHSD17B10MAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808309-A1 | IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS S-ADENOSYLMETHIONINE DECARBOXYLASE (=SAMDC) INHIBITORS | Novartis AG (CH) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996022979-A1 | IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS S-ADENOSYLMETHIONINE DECARBOXYLASE (=SAMDC) INHIBITORS | NOVARTIS AG (CH) | 1996-08-01 | — | — | WO | disclosed |