Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 3/20 | 0.61 |
| ▸ | PDE4A | P27815 | 2/20 | 0.61 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.61 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.61 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.58 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 10/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | NPY1R | P25929 | 1/20 | 0.52 |
| ▸ | NPY2R | P49146 | 1/20 | 0.52 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8890634 | 0.94 | PDE4D (0.60) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL8900252 | 0.87 | PDE4D (0.65) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL8890668 | 0.85 | PDE4D (0.57) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL8900644 | 0.84 | PDE4D (0.56) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL8890864 | 0.83 | THRB (0.51) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL8890753 | 0.81 | MAPT (0.68) | SMPD1MAPTTSHRNPY1RNPY2R | |
| SCHEMBL8901320 | 0.81 | PDE4D (0.56) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL8899650 | 0.78 | PDE4D (0.60) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL8890532 | 0.77 | PDE4D (0.70) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL8889614 | 0.77 | PDE4D (0.73) | PDE4DPDE4APDE4BPDE4CCYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | claimed |
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | disclosed |