Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | CCKBR | P32239 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8899846 | 1.00 | PKM (0.41) | PKMMAPTGAAHDAC8HDAC3 | |
| SCHEMBL8563968 | 0.81 | HDAC8 (0.40) | PKMMAPTGAAHDAC8HDAC3 | |
| Bromide SCHEMBL8565335 | 0.81 | SIRT2 (0.48) | HDAC8HDAC1HDAC6KMT2AMEN1 | |
| Bromide SCHEMBL7619361 | 0.79 | PLA2G10 (0.45) | PKMMAPTALDH1A1POLBSMN1; SMN2 | |
| Bromide SCHEMBL7619358 | 0.79 | PLA2G10 (0.45) | PKMMAPTALDH1A1POLBSMN1; SMN2 | |
| Bromide SCHEMBL8561888 | 0.76 | TGM2 (0.44) | PKMGAAHDAC8ALDH1A1HDAC1 | |
| Bromide SCHEMBL8899312 | 0.76 | TGM2 (0.44) | PKMGAAHDAC8ALDH1A1HDAC1 | |
| Bromide SCHEMBL8563399 | 0.75 | HDAC1 (0.43) | HDAC8ALDH1A1HDAC1HDAC6KMT2A | |
| Bromide SCHEMBL8563395 | 0.75 | HDAC1 (0.43) | HDAC8ALDH1A1HDAC1HDAC6KMT2A | |
| Bromide SCHEMBL8562995 | 0.74 | MAPT (0.38) | MAPTGAAHDAC8ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0761673-A1 | Cephalosporin derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-12 | — | — | EP | disclosed |