Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CETP | P11597 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6119159 | 0.91 | ALOX5 (0.44) | ALOX5ALDH1A1L3MBTL1LMNAPOLB | |
| SCHEMBL7616466 | 0.82 | L3MBTL1 (0.51) | ALOX5L3MBTL1 | |
| SCHEMBL7617078 | 0.82 | ALDH1A1 (0.48) | ALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL7613071 | 0.82 | ALOX5 (0.40) | ALOX5ALDH1A1L3MBTL1LMNAPOLB | |
| SCHEMBL3209123 | 0.79 | ALDH1A1 (0.43) | ALOX5ALDH1A1L3MBTL1PTGS1PTGS2 | |
| SCHEMBL4973395 | 0.78 | ALDH1A1 (0.42) | ALOX5ALDH1A1L3MBTL1PTGS1PTGS2 | |
| SCHEMBL1913624 | 0.78 | ALDH1A1 (0.42) | ALOX5ALDH1A1KMT2AMEN1 | |
| SCHEMBL28343493 | 0.78 | ALDH1A1 (0.46) | ALOX5ALDH1A1L3MBTL1LMNAPOLB | |
| SCHEMBL5267908 | 0.75 | ALOX5 (0.39) | ALOX5ALDH1A1L3MBTL1KMT2AMEN1 | |
| SCHEMBL6120597 | 0.75 | L3MBTL1 (0.47) | ALOX5L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0777471-A1 | INHIBITION OF LEUKOTRIENE BIOSYNTHESIS WITH UREA DERIVATIVES | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1997-06-11 | — | — | EP | disclosed |
| WO-1996003983-A1 | INHIBITION OF LEUKOTRIENE BIOSYNTHESIS WITH UREA DERIVATIVES | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1996-02-15 | — | — | WO | disclosed |