Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.48 |
| ▸ | CYSLTR1 | Q9Y271 | 4/20 | 0.45 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8900513 | 1.00 | ALOX5 (0.48) | ALOX5CYSLTR1CYSLTR2MAOBALOX5AP | |
| SCHEMBL8554759 | 0.82 | CYSLTR2 (0.44) | ALOX5CYSLTR1CYSLTR2ALOX5AP | |
| SCHEMBL8554770 | 0.82 | CYSLTR2 (0.44) | ALOX5CYSLTR1CYSLTR2ALOX5AP | |
| SCHEMBL9054127 | 0.80 | FFAR1 (0.55) | ALOX5CYSLTR1CYSLTR2ALOX5APFFAR1 | |
| SCHEMBL9054057 | 0.79 | NPC1 (0.55) | ALOX5CYSLTR1CYSLTR2ALOX5APFFAR1 | |
| SCHEMBL8900519 | 0.78 | ALOX5 (0.47) | ALOX5CYSLTR1CYSLTR2MAOBALOX5AP | |
| SCHEMBL20543547 | 0.77 | CTBP2 (0.61) | — | |
| SCHEMBL8876557 | 0.75 | CYSLTR1 (0.68) | ALOX5CYSLTR1CYSLTR2ALOX5APFFAR1 | |
| SCHEMBL8878133 | 0.73 | CYSLTR1 (0.51) | ALOX5CYSLTR1CYSLTR2ALOX5APFFAR1 | |
| SCHEMBL8890698 | 0.73 | ALOX5 (0.65) | ALOX5CYSLTR1CYSLTR2FFAR1AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997012866-A1 | BIS-HETEROARYLYLMETHOXYPHENYLKETONE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1997-04-10 | — | — | WO | disclosed |