Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 16/20 | 0.57 |
| ▸ | EDNRB | P24530 | 14/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8900893 | 0.96 | EDNRA (0.59) | EDNRAEDNRB | |
| SCHEMBL8901576 | 0.94 | EDNRA (0.53) | EDNRAEDNRBSMN1; SMN2 | |
| SCHEMBL8902400 | 0.93 | EDNRB (0.65) | EDNRAEDNRB | |
| SCHEMBL8902029 | 0.85 | EDNRA (0.71) | EDNRAEDNRB | |
| SCHEMBL8902138 | 0.81 | EDNRA (0.71) | EDNRAEDNRB | |
| SCHEMBL8900508 | 0.79 | EDNRA (0.78) | EDNRAEDNRB | |
| SCHEMBL8901337 | 0.79 | EDNRA (0.66) | EDNRAEDNRB | |
| SCHEMBL8900589 | 0.78 | EDNRA (0.65) | EDNRAEDNRB | |
| SCHEMBL8901534 | 0.77 | EDNRB (0.69) | EDNRAEDNRB | |
| SCHEMBL8900951 | 0.74 | EDNRB (0.64) | EDNRAEDNRBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5686481-A | INDOLE DERIVATIVES; TREATING HYPERTENSION, RENAL FAILURE, CEREBROVASCULAR DISEASE | SMITHKLINE BEECHAM CORPORATION (US) | 1997-11-11 | — | — | US | disclosed |
| EP-0676959-A4 | ENDOTHELIN RECEPTOR ANTAGONISTS. | SMITHKLINE BEECHAM CORP (US) | 1996-01-03 | — | — | EP | disclosed |
| EP-0676959-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-10-18 | — | — | EP | disclosed |
| WO-1994014434-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-07-07 | — | — | WO | disclosed |