Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.46 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.36 |
| ▸ | FGF23 | Q9GZV9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL978197 | 0.77 | PTGS2 (0.68) | CFTRGOPCPTGS2PTGS1KMT2A | |
| SCHEMBL5395859 | 0.76 | CFTR (0.48) | CFTRGOPCPTGS2PTGS1KMT2A | |
| SCHEMBL5413521 | 0.74 | CFTR (0.46) | CFTRGOPCPTGS2PTGS1KMT2A | |
| SCHEMBL31678688 | 0.74 | PTGS2 (0.50) | CFTRGOPCPTGS2PTGS1KMT2A | |
| SCHEMBL28293315 | 0.74 | CFTR (0.46) | CFTRGOPCPTGS2PTGS1KMT2A | |
| SCHEMBL7212942 | 0.72 | ALDH1A1 (0.53) | CFTRGOPCPTGS2PTGS1KMT2A | |
| SCHEMBL6632882 | 0.72 | PTGS2 (0.62) | CFTRGOPCPTGS2PTGS1KMT2A | |
| SCHEMBL6566571 | 0.72 | CFTR (0.42) | CFTRGOPCPTGS2PTGS1KMT2A | |
| SCHEMBL10298881 | 0.68 | PTGS2 (0.66) | PTGS2PTGS1KMT2AALDH1A1HPGD | |
| SCHEMBL7577906 | 0.68 | PTGS2 (0.61) | CFTRGOPCPTGS2PTGS1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5684205-A | CHLORIDE CHANNEL BLOCKERS FOR CONTROLLING AIRWAY DISEASES, SECRETORY DIARRHEA AND ANTIINFLAMMATORY AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1997-11-04 | — | — | US | disclosed |
| EP-0701988-A1 | Substituted cyclopentane-di- and triones, their preparation and their use as chloride channel blockers | BAYER AG (DE) | 1996-03-20 | — | — | EP | disclosed |