Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CCR4 | P51679 | 6/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9642244 | 0.91 | SCN9A (0.34) | CCR4SCN9A | |
| SCHEMBL9536404 | 0.87 | CCR4 (0.38) | TSHRCCR4 | |
| SCHEMBL8884295 | 0.84 | CCR4 (0.35) | TSHRCCR4SMN1; SMN2 | |
| SCHEMBL9536906 | 0.83 | SMN1; SMN2 (0.34) | PTGS2TSHRCCR4SMN1; SMN2HIF1A | |
| SCHEMBL8848553 | 0.82 | CCR4 (0.39) | TSHRCCR4SMN1; SMN2MAPK1KMT2A | |
| SCHEMBL9534730 | 0.81 | SMN1; SMN2 (0.39) | PTGS2TSHRCCR4FFAR4SMN1; SMN2 | |
| SCHEMBL910148 | 0.80 | TSHR (0.36) | PTGS2TSHRFFAR4MEN1MAPK1 | |
| SCHEMBL909656 | 0.80 | TSHR (0.36) | PTGS2TSHRFFAR4SMN1; SMN2ALDH1A1 | |
| SCHEMBL6244148 | 0.77 | CCR4 (0.39) | TSHRCCR4 | |
| SCHEMBL8556082 | 0.77 | CCR4 (0.41) | TSHRCCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2598540-B2 | — | — | 1997-04-09 | — | — | JP | claimed |
| WO-1989011782-A1 | ALKOXY-1,2,4-TRIAZOLO[1,5-c]PYRIMIDINE-2-SULFONAMIDES, PROCESS FOR THEIR PREPARATION AND INTERMEDIATES | THE DOW CHEMICAL COMPANY (US) | 1989-12-14 | — | — | WO | claimed |
| EP-0343752-A1 | Alkoxy-1,2,4-triazolo (1,5-c) pyrimidine-2-sulfonamides, process for their preparation and intermediates | DowElanco (US) | 1989-11-29 | — | — | EP | claimed |