Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 10/20 | 0.61 |
| ▸ | NPC1 | O15118 | 5/20 | 0.60 |
| ▸ | RAB9A | P51151 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8626723 | 0.83 | ALOX5 (0.72) | ALOX5NPC1RAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL8622657 | 0.82 | ALOX5 (0.71) | ALOX5NPC1RAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL1746753 | 0.78 | SMN1; SMN2 (0.67) | ALOX5NPC1RAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL8890694 | 0.78 | ALOX5 (0.68) | ALOX5 | |
| SCHEMBL9429685 | 0.77 | NPC1 (0.65) | ALOX5NPC1RAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL8136532 | 0.77 | NPC1 (0.73) | ALOX5NPC1RAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL8890266 | 0.77 | ALOX5 (0.67) | ALOX5 | |
| SCHEMBL8901437 | 0.77 | NPC1 (0.61) | ALOX5NPC1RAB9ASMN1; SMN2MAPK1 | |
| SCHEMBL8901453 | 0.77 | NPC1 (0.61) | ALOX5NPC1RAB9ASMN1; SMN2MAPK1 | |
| 2-(Phenoxymethyl)Benzothiazole SCHEMBL2245843 | 0.77 | NPC1 (1.00) | ALOX5NPC1RAB9ASMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997012866-A1 | BIS-HETEROARYLYLMETHOXYPHENYLKETONE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1997-04-10 | — | — | WO | disclosed |