Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UPP1 | Q16831 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | GAA | P10253 | 8/20 | 0.47 |
| ▸ | GLA | P06280 | 7/20 | 0.47 |
| ▸ | HPGD | P15428 | 6/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8901518 | 0.78 | UPP1 (0.61) | UPP1KDM4EALDH1A1GAAGLA | |
| SCHEMBL29771552 | 0.78 | UPP1 (0.52) | UPP1KDM4EALDH1A1GAAGLA | |
| SCHEMBL13280215 | 0.75 | KDM4E (0.49) | UPP1KDM4EALDH1A1GAAGLA | |
| SCHEMBL20340085 | 0.73 | KDM4E (0.44) | UPP1KDM4EALDH1A1GAAGLA | |
| SCHEMBL11835926 | 0.71 | UPP1 (0.49) | UPP1KDM4EALDH1A1GAAGLA | |
| SCHEMBL11051571 | 0.71 | UPP1 (0.56) | UPP1KDM4EALDH1A1GLAHPGD | |
| SCHEMBL1086023 | 0.71 | UPP1 (0.53) | UPP1KDM4EALDH1A1GAAGLA | |
| SCHEMBL11493834 | 0.70 | UPP1 (0.55) | UPP1KDM4EALDH1A1GAAGLA | |
| SCHEMBL25613932 | 0.69 | AR (0.42) | KDM4EALDH1A1GAAGLAHPGD | |
| SCHEMBL20350899 | 0.68 | ALDH1A1 (0.39) | UPP1KDM4EALDH1A1GAAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3997081-A1 | INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS | Escape Bio, Inc. (US) | 2022-05-18 | — | — | EP | disclosed |
| CN-114450274-A | Indazoles and azaindazoles as LRRK2 inhibitors | 伊斯凯普生物公司 | 2022-05-06 | — | — | CN | disclosed |
| WO-2021007477-A1 | INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS | E-SCAPE BIO, INC. (US) | 2021-01-14 | — | — | WO | disclosed |