Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | HTR1A | P08908 | 4/20 | 0.56 |
| ▸ | DRD2 | P14416 | 2/20 | 0.56 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.54 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | HTR1D | P28221 | 1/20 | 0.52 |
| ▸ | HTR1B | P28222 | 1/20 | 0.52 |
| ▸ | HTR7 | P34969 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8902625 | 0.90 | MAPT (0.63) | KMT2AMEN1AVPR2AVPR1ATSHR | |
| SCHEMBL8722757 | 0.90 | DRD2 (0.65) | KMT2AMEN1HTR1ADRD2AVPR2 | |
| SCHEMBL8724506 | 0.89 | HTR1A (0.67) | KMT2AMEN1HTR1ADRD2AVPR2 | |
| SCHEMBL8902187 | 0.89 | HTR1A (0.67) | KMT2AMEN1HTR1ADRD2AVPR2 | |
| SCHEMBL8901177 | 0.89 | HTR1A (0.67) | KMT2AMEN1HTR1ADRD2AVPR2 | |
| SCHEMBL8902126 | 0.86 | KMT2A (0.50) | KMT2AMEN1HTR1AAVPR2AVPR1A | |
| SCHEMBL8901810 | 0.85 | MAPT (0.67) | KMT2AMEN1HTR1ADRD2AVPR2 | |
| SCHEMBL8722760 | 0.85 | MAPT (0.67) | KMT2AMEN1HTR1ADRD2AVPR2 | |
| SCHEMBL8719240 | 0.84 | HTR2A (0.55) | KMT2AMEN1HTR1ADRD2ALDH1A1 | |
| SCHEMBL8919542 | 0.83 | AR (0.51) | KMT2AMEN1HTR1ADRD2AVPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997014689-A1 | ARYL-PIPERAZINE CYCLIC AMINE DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | PIERRE FABRE MEDICAMENT (FR) | 1997-04-24 | — | — | WO | disclosed |