SCHEMBL8902506

SCHEMBL8902506

N#CCC(O)c1cccc(-c2ccccc2)c1

nearest known ligand 0.48

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CTSK P43235 7/20 0.48
CTSS P25774 5/20 0.48
CTSL P07711 4/20 0.48
SLC16A3 O15427 1/20 0.41
TSHR P16473 1/20 0.41
LMNA P02545 3/20 0.40
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
CTSB P07858 1/20 0.40
MMP3 P08254 1/20 0.39
RXRA P19793 1/20 0.38
RXRB P28702 1/20 0.38
RXRG P48443 1/20 0.38
CNR1 P21554 1/20 0.37
CTSA P10619 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29246794 0.84 CTSS (0.44) CTSKCTSSCTSLTSHRLMNA
SCHEMBL23263973 0.84 PNMT (0.46)
SCHEMBL1546681 0.83 TSHR (0.52) TSHRLMNA
SCHEMBL2349389 0.83 TSHR (0.52) TSHRLMNA
SCHEMBL1546683 0.83 TSHR (0.52) TSHRLMNA
SCHEMBL2151108 0.79 HIF1A (0.54) SLC16A3TSHRLMNAMEN1KMT2A
SCHEMBL29818916 0.79 HIF1A (0.54) SLC16A3TSHRLMNAMEN1KMT2A
SCHEMBL2150979 0.79 CPN1 (0.44) TSHR
SCHEMBL17735447 0.79 HIF1A (0.54) SLC16A3TSHRLMNAMEN1KMT2A
SCHEMBL16032729 0.79 CPN1 (0.44) TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103435464-B Preparation method of diphenylethanone SHANDONG CHENGCHUANG PHARMACEUTICAL R & D CO LTD 2014-11-26 CN claimed
CN-103435464-A Preparation method of diphenylethanone SHANDONG CHENGCHUANG PHARMACEUTICAL R & D CO LTD 2013-12-11 CN claimed
CN-103435464-B Preparation method of diphenylethanone SHANDONG CHENGCHUANG PHARMACEUTICAL R & D CO LTD 2014-11-26 CN disclosed
CN-103435464-A Preparation method of diphenylethanone SHANDONG CHENGCHUANG PHARMACEUTICAL R & D CO LTD 2013-12-11 CN disclosed
US-5627189-A Insecticidal 5-substituted-2,4-diaminopyrimidine derivatives FMC CORPORATION (US) 1997-05-06 US disclosed
US-5587379-A CONTROLLING INSECTS IN AGRICULTURAL CROPS FMC CORPORATION (US) 1996-12-24 US disclosed
US-5521192-A TOBACCO BUDWORM, CABBAGE LOOPER, BEET ARMYWORM FMC CORPORATION (US) 1996-05-28 US disclosed
EP-0671881-A4 INSECTICIDAL 5-SUBSTITUTED-2,4-DIAMINOPYRIMIDINE DERIVATIVES. FMC CORP (US) 1996-03-27 EP disclosed
EP-0671881-A1 INSECTICIDAL 5-SUBSTITUTED-2,4-DIAMINOPYRIMIDINE DERIVATIVES FMC CORPORATION (US) 1995-09-20 EP disclosed
WO-1994012032-A1 INSECTICIDAL 5-SUBSTITUTED-2,4-DIAMINOPYRIMIDINE DERIVATIVES FMC CORPORATION (US) 1994-06-09 WO disclosed