SCHEMBL8903130

SCHEMBL8903130

CCCc1ccc(C#Cc2ccc(C(=O)Oc3ccc(F)cc3)cc2)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.51
THRB P10828 3/20 0.51
SMN1; SMN2 Q16637 2/20 0.50
FFAR1 O14842 1/20 0.50
PLA2G1B P04054 1/20 0.47
KMT2A Q03164 1/20 0.47
ATG4B Q9Y4P1 1/20 0.47
ALDH1A1 P00352 1/20 0.47
LMNA P02545 1/20 0.47
GAA P10253 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
MAOB P27338 1/20 0.45
ACACB O00763 5/20 0.44
SENP8 Q96LD8 2/20 0.44
SENP7 Q9BQF6 2/20 0.44
SENP6 Q9GZR1 2/20 0.44
FAAH O00519 1/20 0.44
PRSS1 P07477 1/20 0.44
ACR P10323 1/20 0.44
NPC1 O15118 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8904775 0.93 THRB (0.56) MAPTTHRBSMN1; SMN2PLA2G1BKMT2A
SCHEMBL11307149 0.92 MAPT (0.54) MAPTTHRBSMN1; SMN2PLA2G1BKMT2A
SCHEMBL14770081 0.91 MAOB (0.48) MAPTTHRBSMN1; SMN2FFAR1KMT2A
SCHEMBL17150360 0.88 MAPT (0.54) MAPTTHRBSMN1; SMN2PLA2G1BKMT2A
SCHEMBL9333023 0.88 MAPT (0.52) MAPTTHRBSMN1; SMN2PLA2G1BKMT2A
SCHEMBL8905556 0.88 MAPT (0.52) MAPTTHRBSMN1; SMN2FFAR1PLA2G1B
SCHEMBL8904371 0.88 THRB (0.65) MAPTTHRBSMN1; SMN2PLA2G1BKMT2A
SCHEMBL11099594 0.88 MAPT (0.57) MAPTTHRBSMN1; SMN2PLA2G1BKMT2A
SCHEMBL11099151 0.88 MAPT (0.57) MAPTTHRBSMN1; SMN2PLA2G1BKMT2A
SCHEMBL9333432 0.87 MAPT (0.51) MAPTTHRBSMN1; SMN2FFAR1PLA2G1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5656198-A DISPLAY DEVICE CITIZEN WATCH CO., LTD. (JP) 1997-08-12 US disclosed