Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.54 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.51 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.51 |
| ▸ | GRM5 | P41594 | 2/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.49 |
| ▸ | PRKDC | P78527 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30132372 | 0.85 | PKM (0.57) | PKMGRIN1GRIN2AKDM4EADORA3 | |
| SCHEMBL13151057 | 0.83 | PKM (0.56) | PKMGRIN1GRIN2AKDM4EADORA3 | |
| SCHEMBL12442815 | 0.81 | KDM4E (0.51) | PKMGRIN1GRIN2AKDM4EADORA3 | |
| SCHEMBL2905401 | 0.81 | PKM (0.53) | PKMGRIN1GRIN2AKDM4EADORA3 | |
| SCHEMBL21457878 | 0.81 | KDM4E (0.59) | PKMGRIN1GRIN2AKDM4EADORA3 | |
| SCHEMBL26853240 | 0.80 | PKM (0.52) | PKMGRIN1GRIN2AKDM4EADORA3 | |
| SCHEMBL3963522 | 0.78 | MAPT (0.56) | PKMGRIN1GRIN2AKDM4EADORA3 | |
| SCHEMBL29143358 | 0.78 | PKM (0.54) | PKMGRIN1GRIN2AKDM4EADORA3 | |
| SCHEMBL23725727 | 0.78 | KDM4E (0.43) | PKMGRIN1GRIN2AKDM4EMETTL3 | |
| SCHEMBL17295035 | 0.78 | KDM4E (0.64) | PKMKDM4EMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240368133-A1 | Compounds for the Treatment of Pain, in Particular, Neuropathic Pain, and/or Other Diseases or Disorders that are Associated with AT2R and/or AT2R Mediated Signaling | CONFO THERAPEUTICS N.V. (BE) | 2024-11-07 | — | — | US | disclosed |
| CN-118159530-A | Compounds for the treatment of pain, in particular neuropathic pain and/or other diseases or disorders associated with AT2R and/or AT2R mediated signalling | 康福治疗有限公司 | 2024-06-07 | — | — | CN | disclosed |
| EP-4377307-A1 | COMPOUNDS FOR THE TREATMENT OF PAIN, IN PARTICULAR NEUROPATHIC PAIN, AND/OR OTHER DISEASES OR DISORDERS THAT ARE ASSOCIATED WITH AT2R AND/OR AT2R MEDIATED SIGNALING | Confo Therapeutics N.V. (BE) | 2024-06-05 | — | — | EP | disclosed |
| WO-2023006893-A1 | COMPOUNDS FOR THE TREATMENT OF PAIN, IN PARTICULAR NEUROPATHIC PAIN, AND/OR OTHER DISEASES OR DISORDERS THAT ARE ASSOCIATED WITH AT2R AND/OR AT2R MEDIATED SIGNALING | CONFO THERAPEUTICS N.V. (BE) | 2023-02-02 | — | — | WO | disclosed |
| CN-109942540-B | 1, 4-pentadiene-3-ketone derivative containing thiophene sulfonate, preparation method and application thereof | 贵州大学 | 2021-06-18 | — | — | CN | disclosed |
| US-9034872-B2 | Heterocyclic compounds and uses thereof in the treatment of sexual disorders | ATIR HOLDING S.A. (LU) | 2015-05-19 | — | — | US | disclosed |
| US-8754089-B2 | Heterocyclic compounds and their uses | AMGEN INC. (US) | 2014-06-17 | — | — | US | disclosed |
| US-8754089-B2 | Heterocyclic compounds and their uses | AMGEN INC. (US) | 2014-06-17 | — | — | US | disclosed |
| US-8754089-B2 | Heterocyclic compounds and their uses | AMGEN INC. (US) | 2014-06-17 | — | — | US | disclosed |
| US-20140107128-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF IN THE TREATMENT OF SEXUAL DISORDERS | ATIR HOLDING S.A. | 2014-04-17 | — | — | US | disclosed |
| US-20040171620-A1 | Nitrogen-containing bicyclic heterocycles for use as antibacterials | SMITHKLINE BEECHAM P.L.C. (GB) | 2004-09-02 | — | — | US | disclosed |
| EP-1399443-A1 | NITROGEN-CONTAINING BICYCLIC HETEROCYCLES FOR USE AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 2004-03-24 | — | — | EP | disclosed |
| WO-2003087098-A1 | NITROGEN-CONTAINING BICYCLIC HETEROCYCLES FOR USE AS ANTIBACTERIALS | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-10-23 | — | — | WO | disclosed |
| US-4634690-A | NEMATOCIDES | UNIROYAL CHEMICAL COMPANY, INC. (US) | 1987-01-06 | — | — | US | disclosed |
| EP-0081945-B1 | SUBSTITUTED PYRIMIDINYL ORGANOPHOSPHORUS COMPOUNDS, COMPOSITIONS THEREOF AND METHODS OF CONTROLLING PESTS | UNIROYAL, INC. (US) | 1986-09-03 | — | — | EP | disclosed |
| EP-0156121-A2 | Substituted pyrimidinyl organophosphorus compounds, compositions thereof, methods of controlling pests and intermediates in the preparation of the compounds | UNIROYAL, INC. (US) | 1985-10-02 | — | — | EP | disclosed |
| US-4472389-A | Substituted pyrimidinyl organophosphorus insecticides | UNIROYAL, INC. (US) | 1984-09-18 | — | — | US | disclosed |
| EP-0091700-A2 | Substituted pyrimidinyl organophosphorus compounds, compositions thereof, and methods of controlling pests | UNIROYAL, INC. (US) | 1983-10-19 | — | — | EP | disclosed |
| US-4395551-A | CHEMICAL INTERMEDIATES FOR ORGANOPHOSPHORUS INSECTICIDES | UNIROYAL, INC. (US) | 1983-07-26 | — | — | US | disclosed |
| EP-0081945-A2 | Substituted pyrimidinyl organophosphorus compounds, compositions thereof and methods of controlling pests | UNIROYAL, INC. (US) | 1983-06-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040171620-A1 | Nitrogen-containing bicyclic heterocycles for use as antibacterials | NRDC, NUCB2, NDC1 | PKM 4251/4885GRIN1 2219/4885GRIN2A 3490/4885 |
| US-20240368133-A1 | Compounds for the Treatment of Pain, in Particular, Neuropathic Pain, and/or Other Diseases or Disorders that are Associated with AT2R and/or AT2R Mediated Signaling | AGTR2, AGTR1, OPRL1 | PKM 1694/4885GRIN1 285/4885GRIN2A 160/4885 |
| US-20140107128-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF IN THE TREATMENT OF SEXUAL DISORDERS | PDE5A, PDE3B, PDE3A | PKM 368/4885GRIN1 1334/4885GRIN2A 1002/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.