Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.39 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL10383607 | 0.88 | CYP3A4 (0.44) | PPARGPTGESALOX5MEN1NR1I2 | |
| Bromide SCHEMBL10383345 | 0.88 | CYP3A4 (0.44) | PPARGPTGESALOX5MEN1NR1I2 | |
| Hydrochloric Acid SCHEMBL10008405 | 0.87 | L3MBTL1 (0.38) | PPARGPTGESALOX5MEN1NR1I2 | |
| Bromide SCHEMBL3697333 | 0.82 | TLR8 (0.42) | PPARGPTGESALOX5MEN1NR1I2 | |
| Bromide SCHEMBL3593928 | 0.82 | CYP1A2 (0.47) | PPARGPTGESALOX5CYP3A4MAPT | |
| Bromide SCHEMBL4171091 | 0.78 | SLC6A2 (0.47) | PPARGPTGESALOX5MEN1CYP3A4 | |
| Bromide SCHEMBL10383353 | 0.77 | S1PR1 (0.38) | PPARGMEN1NR1I2LMNACHRM2 | |
| SCHEMBL8903543 | 0.76 | MCHR1 (0.43) | ALOX5MEN1NR1I2LMNACHRM2 | |
| SCHEMBL8903015 | 0.76 | MEN1 (0.47) | ALOX5MEN1NR1I2LMNACHRM2 | |
| Bromide SCHEMBL10383605 | 0.76 | CYSLTR2 (0.46) | PPARGPTGESALOX5MEN1NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5648021-A | Phenanthrene derivatives and their use in liquid-crystalline mixtures | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-07-15 | — | — | US | disclosed |