Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8662656 | 1.00 | LMNA (0.46) | LMNAALDH1A1CYP2C19HSD17B10GABRA1 | |
| SCHEMBL8659050 | 0.86 | DPP4 (0.46) | LMNAALDH1A1GABRA1GABRG2GABRB3 | |
| SCHEMBL8903556 | 0.86 | DPP4 (0.46) | LMNAALDH1A1GABRA1GABRG2GABRB3 | |
| SCHEMBL6490375 | 0.84 | ALDH1A1 (0.66) | LMNAALDH1A1CYP2C19HSD17B10NPC1 | |
| SCHEMBL6490384 | 0.84 | ALDH1A1 (0.66) | LMNAALDH1A1CYP2C19HSD17B10NPC1 | |
| SCHEMBL8659535 | 0.80 | ALDH1A1 (0.69) | LMNAALDH1A1CYP2C19HSD17B10GABRA1 | |
| SCHEMBL6478007 | 0.79 | ABCB1 (0.48) | LMNAALDH1A1CYP2C19HSD17B10NPC1 | |
| SCHEMBL6478016 | 0.79 | ABCB1 (0.48) | LMNAALDH1A1CYP2C19HSD17B10NPC1 | |
| SCHEMBL9763854 | 0.77 | TACR1 (0.47) | LMNATACR1SMN1; SMN2KMT2APADI4 | |
| SCHEMBL9763860 | 0.77 | TACR1 (0.47) | LMNATACR1SMN1; SMN2KMT2APADI4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5665733-A | 3-phenylisoquinol-1(2H)-one derivatives their preparation and their therapeutic application | SYNTHELABO (FR) | 1997-09-09 | — | — | US | disclosed |