Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.45 |
| ▸ | CYP21A2 | P08686 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.43 |
| ▸ | CYP4F11 | Q9HBI6 | 1/20 | 0.43 |
| ▸ | CYP4F12 | Q9HCS2 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7403781 | 0.89 | DRD4 (0.52) | DRD4SLC6A4POLBKMT2AHRH3 | |
| SCHEMBL7397902 | 0.85 | DRD4 (0.54) | DRD4SLC6A4POLBKMT2AS1PR1 | |
| SCHEMBL7403454 | 0.83 | DRD4 (0.59) | DRD4SLC6A4POLBS1PR1HTR1A | |
| Hydrochloric Acid SCHEMBL8838070 | 0.82 | HRH3 (0.56) | DRD4SLC6A4HRH3 | |
| SCHEMBL8837972 | 0.82 | HRH3 (0.57) | DRD4SLC6A4HRH3HTR1A | |
| SCHEMBL7493712 | 0.80 | DRD4 (0.61) | DRD4SLC6A4POLBS1PR1HTR1A | |
| SCHEMBL8634749 | 0.80 | HRH3 (0.48) | DRD4SLC6A4POLBKMT2AHRH3 | |
| SCHEMBL27469498 | 0.79 | ALOX5 (0.56) | FAAHMEN1KMT2AALDH1A1CYP4Z1 | |
| SCHEMBL7334450 | 0.77 | HRH3 (0.57) | FAAHMAPTHRH3 | |
| SCHEMBL6134491 | 0.77 | POLB (0.54) | POLBMEN1MAPTHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5652242-A | 3-METHYL-4-(4-(4-(4-PYRIDYL)PIPERAZIN-1-YL)PHENOXY)BURYIC ACID, AMIDE OR ESTER; INHIBITORS OF BINDING OF FIBRINOGEN TO GLYCOPROTEIN | ZENECA LIMITED (GB) | 1997-07-29 | — | — | US | disclosed |