Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.48 |
| ▸ | HRH1 | P35367 | 2/20 | 0.45 |
| ▸ | PPARD | Q03181 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | LSS | P48449 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8905952 | 0.80 | DRD4 (0.50) | HRH3POLBKMT2AALDH1A1KDM4E | |
| SCHEMBL8634144 | 0.80 | HRH3 (0.57) | HRH3HRH1 | |
| SCHEMBL7403781 | 0.80 | DRD4 (0.52) | HRH3POLBLSSKMT2AALDH1A1 | |
| SCHEMBL8701067 | 0.79 | HRH3 (0.58) | HRH3HRH1DRD4SLC6A4 | |
| SCHEMBL7397902 | 0.79 | DRD4 (0.54) | HRH3POLBLSSKMT2AALDH1A1 | |
| SCHEMBL8637843 | 0.77 | HRH3 (0.60) | HRH3HRH1SMN1; SMN2ALDH1A1DRD4 | |
| SCHEMBL16944454 | 0.77 | SIGMAR1 (0.60) | POLBLSSKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL7812327 | 0.76 | LMNA (0.51) | KMT2ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL8630602 | 0.76 | HRH3 (0.59) | HRH3HRH1SMN1; SMN2ALDH1A1DRD4 | |
| SCHEMBL8251460 | 0.75 | POLB (0.56) | POLBLSSKDM4EDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753659-A | ANTICOAGULANTS FOR BLOOD DISORDER, CARDIOVASCULAR DISORDER, THROMBOSIS, | ZENECA LIMITED (GB) | 1998-05-19 | — | — | US | disclosed |
| US-5728701-A | INHIBIT PLATELET AGGREGATION | ZENECA LIMITED (GB) | 1998-03-17 | — | — | US | disclosed |