Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SRR | Q9GZT4 | 2/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | ALPI | P09923 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3206845 | 0.76 | CYP1A2 (0.46) | KMT2ACYP1A2CHRM1SRREPHX1 | |
| SCHEMBL8906122 | 0.76 | CHRM1 (0.39) | NPSR1HSD17B10MAPTKMT2AMEN1 | |
| SCHEMBL11845837 | 0.74 | EPHX1 (0.52) | ALDH1A1HTTCYP1A2CHRM1SRR | |
| SCHEMBL9067637 | 0.74 | EPHX1 (0.52) | ALDH1A1HTTCYP1A2CHRM1SRR | |
| SCHEMBL27726511 | 0.74 | EPHX1 (0.52) | ALDH1A1HTTCYP1A2SRREPHX1 | |
| Hydrochloric Acid SCHEMBL11845834 | 0.73 | EPHX1 (0.50) | ALDH1A1HTTCYP1A2CHRM1SRR | |
| SCHEMBL11704440 | 0.72 | CTSB (0.46) | CYP1A2 | |
| SCHEMBL29740764 | 0.72 | PABPC1 (0.54) | KMT2ATSHRALDH1A1CYP1A2CHRM1 | |
| SCHEMBL29740763 | 0.72 | PABPC1 (0.54) | KMT2ATSHRALDH1A1CYP1A2CHRM1 | |
| SCHEMBL7655431 | 0.72 | EPHX1 (0.58) | NPSR1CYP1A2SRREPHX1ALPI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0520320-B1 | Tetrahydropyrrolo[1,2-a]pyrazine-4-spiro-3'-pyrrolidine derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same | DAINIPPON PHARMACEUTICAL CO (JP) | 1997-09-10 | — | — | EP | disclosed |
| US-5258382-A | Antidiabetic agents or reductase inhibitors | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1993-11-02 | — | — | US | disclosed |
| EP-0520320-A2 | Tetrahydropyrrolo 1,2-a pyrazine-4-spiro-3'-pyrrolidine derivatives, processes for the preparation thereof and pharaceutical compositions containing the same | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1992-12-30 | — | — | EP | disclosed |