Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 6/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8906288 | 0.76 | NPSR1 (0.53) | CHRM1EPHX1HSD17B10NPSR1ALDH1A1 | |
| SCHEMBL8907494 | 0.72 | KMT2A (0.36) | HTTSMN1; SMN2MEN1KMT2ACYP2C9 | |
| SCHEMBL24967415 | 0.71 | CYP1A2 (0.40) | MAOBKMT2ACYP2C9CYP2C19KDM4E | |
| SCHEMBL24966945 | 0.71 | ALDH1A1 (0.47) | HSD17B10ALDH1A1HTTMEN1KMT2A | |
| SCHEMBL3206845 | 0.67 | CYP1A2 (0.46) | CHRM1EPHX1KMT2ACYP1A2CYP2D6 | |
| SCHEMBL11704440 | 0.67 | CTSB (0.46) | CYP1A2 | |
| SCHEMBL7655431 | 0.66 | EPHX1 (0.58) | EPHX1NPSR1SMN1; SMN2CYP1A2CYP2D6 | |
| SCHEMBL29740763 | 0.66 | PABPC1 (0.54) | CHRM1EPHX1ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL29740764 | 0.66 | PABPC1 (0.54) | CHRM1EPHX1ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL11845837 | 0.66 | EPHX1 (0.52) | CHRM1EPHX1ALDH1A1HTTNCOA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0520320-B1 | Tetrahydropyrrolo[1,2-a]pyrazine-4-spiro-3'-pyrrolidine derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same | DAINIPPON PHARMACEUTICAL CO (JP) | 1997-09-10 | — | — | EP | disclosed |
| US-5258382-A | Antidiabetic agents or reductase inhibitors | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1993-11-02 | — | — | US | disclosed |
| EP-0520320-A2 | Tetrahydropyrrolo 1,2-a pyrazine-4-spiro-3'-pyrrolidine derivatives, processes for the preparation thereof and pharaceutical compositions containing the same | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1992-12-30 | — | — | EP | disclosed |