Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 7/20 | 0.38 |
| ▸ | MAOB | P27338 | 7/20 | 0.38 |
| ▸ | KDM1A | O60341 | 4/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.30 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17414858 | 0.74 | MAOA (0.47) | MAOAMAOBKDM1AHSD11B1LMNA | |
| SCHEMBL8155755 | 0.74 | MAOA (0.38) | MAOAMAOBKDM1AHSD11B1OPRM1 | |
| SCHEMBL9462490 | 0.74 | MAOA (0.39) | MAOAMAOBKDM1ALMNA | |
| SCHEMBL7894379 | 0.73 | MAOA (0.37) | MAOAMAOBKDM1AHSD11B1LMNA | |
| SCHEMBL9750269 | 0.73 | MAOA (0.37) | MAOAMAOBKDM1AHSD11B1OPRM1 | |
| Hydrochloric Acid SCHEMBL10383764 | 0.73 | MAOA (0.38) | MAOAMAOBKDM1ALMNA | |
| SCHEMBL7110744 | 0.71 | MAOA (0.40) | MAOAMAOBKDM1AHSD11B1 | |
| SCHEMBL20377192 | 0.70 | HSD11B1 (0.39) | MAOAMAOBHSD11B1LMNAHTT | |
| SCHEMBL6142862 | 0.70 | TSHR (0.36) | L3MBTL1OPRM1OPRK1OPRL1 | |
| SCHEMBL29700255 | 0.69 | MAOA (0.34) | MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607931-A | AMIDES | SCHERING CORPORATION (US) | 1997-03-04 | — | — | US | disclosed |
| EP-0662965-A1 | 1,2-DISUBSTITUTED ETHYL AMIDES AS INHIBITORS OF ACAT | SCHERING CORPORATION (US) | 1995-07-19 | — | — | EP | disclosed |
| US-5326762-A | Heterocyclic substituted amides | SCHERING CORPORATION (US) | 1994-07-05 | — | — | US | disclosed |
| US-5321031-A | Treating cardiovascular disorders | SCHERING CORPORATION (US) | 1994-06-14 | — | — | US | disclosed |
| WO-1994006784-A1 | 1,2-DISUBSTITUTED ETHYL AMIDES AS INHIBITORS OF ACAT | SCHERING CORPORATION (US) | 1994-03-31 | — | — | WO | disclosed |
| US-5149709-A | Treatment of atherosclerosis | SCHERING CORPORATION (US) | 1992-09-22 | — | — | US | disclosed |