Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.51 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.51 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | PRKDC | P78527 | 1/20 | 0.46 |
| ▸ | CCR1 | P32246 | 3/20 | 0.45 |
| ▸ | CCR5 | P51681 | 3/20 | 0.45 |
| ▸ | CCR8 | P51685 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32688240 | 0.80 | MAPT (0.52) | RAD51KDM5BKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL1659994 | 0.79 | KDM4E (0.52) | GRM5ADORA3RAD51KDM5BKDM4E | |
| SCHEMBL1834856 | 0.78 | ADORA3 (0.47) | GRM5ADORA3KDM5BKDM4EMAPT | |
| SCHEMBL8092386 | 0.74 | NPC1 (0.55) | ADORA3RAD51KDM5BKDM4EMAPT | |
| SCHEMBL8099804 | 0.74 | RAB9A (0.49) | GRM5ADORA3KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL8105987 | 0.74 | NPC1 (0.55) | GRM5ADORA3KDM5BKDM4EMAPT | |
| SCHEMBL890511 | 0.74 | DPP4 (0.49) | GRM5ADORA3KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL910159 | 0.74 | KDM4E (0.43) | GRM5ADORA3KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL20602860 | 0.74 | ADORA3 (0.61) | GRM5ADORA3KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL3958034 | 0.73 | KDM4E (0.55) | GRM5ADORA3KDM4EMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120083502-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2012-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120083502-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | MCL1, MALT1, BCL9 | GRM5 2946/4885ADORA3 2668/4885RAD51 1988/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.