SCHEMBL8907372

SCHEMBL8907372

O=C1c2ccccc2-c2[nH]c(=O)c(=O)[nH]c21

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 4/20 0.67
RAB9A P51151 3/20 0.67
APAF1 O14727 3/20 0.67
PAX8 Q06710 1/20 0.67
MEN1 O00255 3/20 0.50
KMT2A Q03164 3/20 0.50
CDC25B P30305 3/20 0.50
USP8 P40818 1/20 0.49
USP7 Q93009 1/20 0.49
KDM4E B2RXH2 3/20 0.48
MAPT P10636 3/20 0.48
LMNA P02545 2/20 0.48
BLM P54132 2/20 0.48
SMN1; SMN2 Q16637 2/20 0.48
TDP2 O95551 2/20 0.48
S100A4 P26447 2/20 0.48
MAOA P21397 2/20 0.48
CES2 O00748 1/20 0.48
TERT O14746 1/20 0.48
NPC1 O15118 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5465434 0.73 POLB (0.50) POLBRAB9AAPAF1PAX8MEN1
SCHEMBL8907251 0.73 MEN1 (0.50) POLBRAB9AAPAF1PAX8MEN1
SCHEMBL8907252 0.73 MEN1 (0.50) POLBRAB9AAPAF1PAX8MEN1
SCHEMBL29941542 0.73 SERPINE1 (0.46) POLBRAB9AAPAF1PAX8MEN1
SCHEMBL8907257 0.73 MEN1 (0.50) POLBRAB9AAPAF1PAX8MEN1
SCHEMBL2765272 0.73 SERPINE1 (0.46) POLBRAB9AAPAF1PAX8MEN1
Anthraquinone SCHEMBL27827404 0.73 MEN1 (0.92) POLBRAB9AAPAF1PAX8MEN1
SCHEMBL8916400 0.71 RAB9A (0.48) POLBRAB9AAPAF1PAX8MEN1
Anthraquinone SCHEMBL7915429 0.70 MEN1 (0.86) POLBRAB9AAPAF1MEN1KMT2A
SCHEMBL4859240 0.70 POLB (0.69) POLBRAB9AAPAF1PAX8MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012107262-A1 DIHYDROBENZOPYRAN, THIOCHROMAN, TETRAHYDROQUINOLEINE AND TETRAHYDRONAPHTALENE DERIVATIVES AND THEIR USE IN ANTICANCER THERAPY UNIVERSITE DE LIEGE (BE) 2012-08-16 WO claimed
EP-0682657-B1 9H-INDENO[1,2-b]PYRAZINE-3(4H)-ONES AND 9H-INDENO[1,2-b]PYRAZINE-2,3(1H,4H)-DIONES AND THEIR PREPARATION AND USE NOVO NORDISK AS (DK) 1997-11-19 EP claimed
US-5646146-A CENTRAL NERVOUS SYSTEM DISORDERS NOVO NORDISK A/S (DK) 1997-07-08 US claimed
EP-0682657-A1 9H-INDENO[1,2-b]PYRAZINE-3(4H)-ONES AND 9H-INDENO[1,2-b]PYRAZINE-2,3(1H,4H)-DIONES AND THEIR PREPARATION AND USE NOVO NORDISK A/S (DK) 1995-11-22 EP claimed
WO-1994018175-A1 HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE NOVO NORDISK A/S (DK) 1994-08-18 WO claimed
EP-2646425-A1 INDANYLOXYDIHYDROBENZOFURANYLACETIC ACIDS Boehringer Ingelheim International GmbH (DE) 2013-10-09 EP disclosed
WO-2012107262-A1 DIHYDROBENZOPYRAN, THIOCHROMAN, TETRAHYDROQUINOLEINE AND TETRAHYDRONAPHTALENE DERIVATIVES AND THEIR USE IN ANTICANCER THERAPY UNIVERSITE DE LIEGE (BE) 2012-08-16 WO disclosed
WO-2012072691-A1 INDANYLOXYDIHYDROBENZOFURANYLACETIC ACIDS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2012-06-07 WO disclosed
EP-0682657-B1 9H-INDENO[1,2-b]PYRAZINE-3(4H)-ONES AND 9H-INDENO[1,2-b]PYRAZINE-2,3(1H,4H)-DIONES AND THEIR PREPARATION AND USE NOVO NORDISK AS (DK) 1997-11-19 EP disclosed
US-5646146-A CENTRAL NERVOUS SYSTEM DISORDERS NOVO NORDISK A/S (DK) 1997-07-08 US disclosed
EP-0682657-A1 9H-INDENO[1,2-b]PYRAZINE-3(4H)-ONES AND 9H-INDENO[1,2-b]PYRAZINE-2,3(1H,4H)-DIONES AND THEIR PREPARATION AND USE NOVO NORDISK A/S (DK) 1995-11-22 EP disclosed
US-5468748-A Nervous system and psychological disorders; antagonize glycine binding site on N-methylaspartic acid receptor complex NOVO NORDISK A/S (DK) 1995-11-21 US disclosed
WO-1994018175-A1 HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE NOVO NORDISK A/S (DK) 1994-08-18 WO disclosed