Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.69 |
| ▸ | RAB9A | P51151 | 3/20 | 0.69 |
| ▸ | APAF1 | O14727 | 3/20 | 0.69 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.69 |
| ▸ | TYMP | P19971 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | CDC25B | P30305 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | MAOA | P21397 | 3/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.42 |
| ▸ | FGR | P09769 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10820339 | 0.73 | APAF1 (0.39) | POLBRAB9AAPAF1PAX8TYMP | |
| Benzocarbazoledione SCHEMBL22541347 | 0.72 | MAOA (0.54) | POLBRAB9AAPAF1PAX8KDM4E | |
| SCHEMBL5465434 | 0.71 | POLB (0.50) | POLBRAB9AAPAF1PAX8KDM4E | |
| SCHEMBL8907372 | 0.70 | POLB (0.67) | POLBRAB9AAPAF1PAX8KDM4E | |
| SCHEMBL1572915 | 0.69 | ALDH1A1 (0.68) | POLBRAB9AAPAF1PAX8TYMP | |
| SCHEMBL30480799 | 0.68 | PTPRC (0.54) | POLBRAB9AAPAF1PAX8KDM4E | |
| Dielsiquinone SCHEMBL31237174 | 0.67 | MAPT (0.47) | POLBRAB9AAPAF1PAX8KDM4E | |
| SCHEMBL8920440 | 0.67 | RAB9A (0.56) | POLBRAB9AAPAF1PAX8KDM4E | |
| SCHEMBL2765272 | 0.67 | SERPINE1 (0.46) | POLBRAB9AAPAF1PAX8KDM4E | |
| SCHEMBL13043812 | 0.65 | MAPK14 (0.52) | POLBRAB9AAPAF1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080139476-A1 | CASPASE-8 INTERACTING PROTEINS | YEDA RESEARCH AND DEVELOPMENT COMPANY LTD. (IL) | 2008-06-12 | — | — | US | disclosed |
| US-7339047-B2 | Caspase-8 interacting proteins | YEDA RESEARCH AND DEVELOPMENT COMPANY LTD. (IL) | 2008-03-04 | — | — | US | disclosed |
| US-20040229260-A1 | Caspase-8 interacting proteins | YEDA RESEARCH AND DEVELOPMENT COMPANY LTD (IL) | 2004-11-18 | — | — | US | disclosed |
| US-6762283-B1 | Caspase-8 interacting proteins | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2004-07-13 | — | — | US | disclosed |
| EP-1058691-A1 | CASPASE-8 INTERACTING PROTEINS | YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD. (IL) | 2000-12-13 | — | — | EP | disclosed |
| WO-2000039160-A2 | CASPASE-8 INTERACTING PROTEINS | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2000-07-06 | — | — | WO | disclosed |