Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.49 |
| ▸ | FERMT2 | Q96AC1 | 1/20 | 0.45 |
| ▸ | NCF1 | P14598 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15924893 | 0.98 | LOXL2 (0.47) | LOXL2FERMT2NCF1HTR1AADRA1D | |
| SCHEMBL15924403 | 0.95 | LOXL2 (0.50) | LOXL2FERMT2NCF1HTR1AADRA1D | |
| SCHEMBL8907514 | 0.86 | LOXL2 (0.44) | LOXL2FERMT2NCF1HTR1AADRA1D | |
| SCHEMBL8908581 | 0.85 | KDM4E (0.45) | LOXL2FERMT2NCF1HTR1AADRA1D | |
| SCHEMBL14163267 | 0.84 | FERMT2 (0.47) | LOXL2FERMT2NCF1HTR1AADRA1D | |
| SCHEMBL9186226 | 0.81 | LOXL2 (0.47) | LOXL2FERMT2NCF1HTR1AADRA1D | |
| SCHEMBL4367045 | 0.80 | FERMT2 (0.56) | FERMT2MAPTCYP2D6CYP1A2CYP3A4 | |
| SCHEMBL263407 | 0.77 | LOXL2 (0.50) | LOXL2FERMT2NCF1HTR1AADRA1D | |
| SCHEMBL277463 | 0.77 | LOXL2 (0.50) | LOXL2FERMT2NCF1HTR1AADRA1D | |
| SCHEMBL8908132 | 0.77 | LOXL2 (0.50) | LOXL2FERMT2NCF1HTR1AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10774046-B2 | Inhibitors for the treatment of cancer and related methods | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2020-09-15 | — | — | US | disclosed |
| US-20190127329-A1 | INHIBITORS FOR THE TREATMENT OF CANCER AND RELATED METHODS | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2019-05-02 | — | — | US | disclosed |
| WO-1997048705-A1 | POTASSIUM CHANNEL BLOCKERS | UNIVERSITY COLLEGE LONDON (GB) | 1997-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10774046-B2 | Inhibitors for the treatment of cancer and related methods | PFKFB4, PDK4, PFKFB1 | LOXL2 4581/4885FERMT2 220/4885NCF1 4187/4885 |
| US-20190127329-A1 | INHIBITORS FOR THE TREATMENT OF CANCER AND RELATED METHODS | PFKFB4, PDK4, PFKFB1 | LOXL2 4581/4885FERMT2 220/4885NCF1 4187/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.