Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 7/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.49 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HNF4A | P41235 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RARG | P13631 | 2/20 | 0.43 |
| ▸ | RARB | P10826 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | RARA | P10276 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.42 |
| ▸ | RXRG | P48443 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8908720 | 0.90 | CYP3A4 (0.54) | RXRACYP3A4CYP26A1CYP26B1NPC1 | |
| SCHEMBL8907762 | 0.87 | L3MBTL1 (0.49) | RXRACYP3A4CYP26A1CYP26B1NPC1 | |
| SCHEMBL9269947 | 0.84 | RXRA (0.49) | RXRACYP3A4CYP26A1CYP26B1HNF4A | |
| SCHEMBL5184246 | 0.82 | CYP26A1 (0.74) | RXRACYP3A4CYP26A1CYP26B1RARG | |
| SCHEMBL8908240 | 0.80 | CYP26A1 (0.48) | RXRACYP3A4CYP26A1CYP26B1HNF4A | |
| SCHEMBL9262524 | 0.79 | RXRA (0.48) | RXRACYP3A4CYP26A1CYP26B1HNF4A | |
| SCHEMBL8704549 | 0.78 | RXRA (0.71) | RXRACYP26A1CYP26B1KMT2AHNF4A | |
| SCHEMBL8907597 | 0.76 | MAOB (0.49) | RXRACYP3A4CYP26A1CYP26B1NPC1 | |
| SCHEMBL8907781 | 0.75 | MAOB (0.53) | RXRACYP3A4CYP26A1CYP26B1MAPT | |
| SCHEMBL9194990 | 0.75 | RARG (0.52) | RXRACYP3A4CYP26A1CYP26B1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5654331-A | SKIN AND RESPIRATORY SYSTEM DISORDERS; ANTIINFLAMMATORY AGENTS; ANTIALLERGENS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (CIRD GALDERMA) (FR) | 1997-08-05 | — | — | US | disclosed |
| US-5476860-A | Diaromatic compounds derived from a salicylic unit and their use in human and veterinary medicine and in cosmetics | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (CIRD GALDERMA) (FR) | 1995-12-19 | — | — | US | disclosed |