Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.50 |
| ▸ | SMPD1 | P17405 | 5/20 | 0.49 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.47 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.47 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.46 |
| ▸ | CHUK | O15111 | 1/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | PRKCG | P05129 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 1/20 | 0.45 |
| ▸ | AKT2 | P31751 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7271422 | 1.00 | THRA (0.51) | THRATHRBPLA2G4BSMPD1S1PR2 | |
| SCHEMBL6194741 | 0.91 | CHUK (0.46) | THRATHRBPLA2G4BSMPD1S1PR2 | |
| SCHEMBL7996217 | 0.85 | ALDH1A1 (0.50) | THRATHRBPLA2G4BSMPD1PRSS1 | |
| SCHEMBL9524559 | 0.83 | PDE4A (0.46) | SMPD1HPGD | |
| SCHEMBL9528325 | 0.83 | FDPS (0.50) | ALDH1A1HPGD | |
| SCHEMBL2702025 | 0.82 | MAPT (0.54) | ALDH1A1HPGD | |
| SCHEMBL9530159 | 0.81 | KMT2A (0.50) | PRSS1ALDH1A1 | |
| SCHEMBL8975125 | 0.79 | THRA (0.53) | THRATHRBPLA2G4BSMPD1S1PR2 | |
| SCHEMBL10723938 | 0.79 | MEN1 (0.48) | ALDH1A1 | |
| SCHEMBL2163665 | 0.78 | AR (0.55) | PLA2G4BPRKCDALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0662965-A1 | 1,2-DISUBSTITUTED ETHYL AMIDES AS INHIBITORS OF ACAT | SCHERING CORPORATION (US) | 1995-07-19 | — | — | EP | claimed |
| US-5416118-A | Enzyme inhibitors | SCHERING CORPORATION (US) | 1995-05-16 | — | — | US | claimed |
| WO-1994006784-A1 | 1,2-DISUBSTITUTED ETHYL AMIDES AS INHIBITORS OF ACAT | SCHERING CORPORATION (US) | 1994-03-31 | — | — | WO | claimed |
| EP-0583346-A1 | BICYCLIC AMIDES AS INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL ACYL TRANSFERASE | SCHERING CORPORATION (US) | 1994-02-23 | — | — | EP | claimed |
| EP-0514851-A1 | N-acyl-tetrahydroisoquinolines as inhibitors of acyl-coenzyme a:cholesterol acyl transferase | SCHERING CORPORATION (US) | 1992-11-25 | — | — | EP | claimed |
| WO-1992018462-A1 | BICYCLIC AMIDES AS INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL ACYL TRANSFERASE | SCHERING CORPORATION (US) | 1992-10-29 | — | — | WO | claimed |
| EP-0508425-A1 | Bicyclic amides as inhibitors of acyl-coenzyme a: cholesterol acyl transferase | SCHERING CORPORATION (US) | 1992-10-14 | — | — | EP | claimed |
| US-5124337-A | Treating atherosclerosis | SCHERING CORPORATION (US) | 1992-06-23 | — | — | US | claimed |
| US-5607931-A | AMIDES | SCHERING CORPORATION (US) | 1997-03-04 | — | — | US | disclosed |
| EP-0662965-A1 | 1,2-DISUBSTITUTED ETHYL AMIDES AS INHIBITORS OF ACAT | SCHERING CORPORATION (US) | 1995-07-19 | — | — | EP | disclosed |
| US-5416118-A | Enzyme inhibitors | SCHERING CORPORATION (US) | 1995-05-16 | — | — | US | disclosed |
| US-5326762-A | Heterocyclic substituted amides | SCHERING CORPORATION (US) | 1994-07-05 | — | — | US | disclosed |
| US-5321031-A | Treating cardiovascular disorders | SCHERING CORPORATION (US) | 1994-06-14 | — | — | US | disclosed |
| WO-1994006784-A1 | 1,2-DISUBSTITUTED ETHYL AMIDES AS INHIBITORS OF ACAT | SCHERING CORPORATION (US) | 1994-03-31 | — | — | WO | disclosed |
| US-5238935-A | Treating atherosclerosis | SCHERING CORPORATION (US) | 1993-08-24 | — | — | US | disclosed |
| EP-0514851-A1 | N-acyl-tetrahydroisoquinolines as inhibitors of acyl-coenzyme a:cholesterol acyl transferase | SCHERING CORPORATION (US) | 1992-11-25 | — | — | EP | disclosed |
| WO-1992018462-A1 | BICYCLIC AMIDES AS INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL ACYL TRANSFERASE | SCHERING CORPORATION (US) | 1992-10-29 | — | — | WO | disclosed |
| EP-0508425-A1 | Bicyclic amides as inhibitors of acyl-coenzyme a: cholesterol acyl transferase | SCHERING CORPORATION (US) | 1992-10-14 | — | — | EP | disclosed |
| US-5149709-A | Treatment of atherosclerosis | SCHERING CORPORATION (US) | 1992-09-22 | — | — | US | disclosed |
| US-5124337-A | Treating atherosclerosis | SCHERING CORPORATION (US) | 1992-06-23 | — | — | US | disclosed |