Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | TOP2A | P11388 | 1/20 | 0.52 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.52 |
| ▸ | CASP6 | P55212 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 6/20 | 0.49 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.47 |
| ▸ | TRIM58 | Q8NG06 | 1/20 | 0.47 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | CCR4 | P51679 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8890083 | 1.00 | POLB (0.55) | POLBTOP2ASLC2A1CASP6GAA | |
| SCHEMBL8898707 | 0.94 | FLT3 (0.48) | POLBTOP2ASLC2A1CASP6FLT3 | |
| SCHEMBL8899155 | 0.90 | TRIM58 (0.57) | POLBTOP2ASLC2A1CASP6FLT3 | |
| SCHEMBL8907323 | 0.90 | TRIM58 (0.57) | POLBTOP2ASLC2A1CASP6FLT3 | |
| SCHEMBL8890072 | 0.88 | POLB (0.51) | POLBTOP2ASLC2A1CASP6GAA | |
| SCHEMBL8898947 | 0.85 | TLR9 (0.51) | POLBTOP2ACASP6GAAFLT3 | |
| SCHEMBL8899104 | 0.84 | NPY5R (0.54) | POLBTOP2ASLC2A1CASP6GAA | |
| SCHEMBL8899107 | 0.84 | NPY5R (0.54) | POLBTOP2ASLC2A1CASP6GAA | |
| SCHEMBL8901747 | 0.84 | TAAR1 (0.56) | POLBSLC2A1GAASOS1APP | |
| SCHEMBL8898278 | 0.84 | SOS1 (0.52) | CASP6TRIM58SOS1ADRA2ANPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997020823-A2 | 2-AMINO QUINAZOLINE DERIVATIVES AS NPY RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 1997-06-12 | — | — | WO | disclosed |