SCHEMBL8908376

SCHEMBL8908376

C=CCc1c(OC)ccc(OC)c1C=O

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 0.51
KDM4E B2RXH2 2/20 0.51
HPGD P15428 1/20 0.51
PPARG P37231 1/20 0.47
PPARD Q03181 1/20 0.47
PPARA Q07869 1/20 0.47
PTGS1 P23219 2/20 0.42
ERN1 O75460 1/20 0.41
ESR1 P03372 1/20 0.41
ESR2 Q92731 1/20 0.41
POLB P06746 2/20 0.41
CYP3A4 P08684 3/20 0.40
ALOX5 P09917 2/20 0.40
AR P10275 1/20 0.40
TRPM8 Q7Z2W7 1/20 0.40
GABRA1 P14867 2/20 0.40
GABRB2 P47870 2/20 0.40
TDP1 Q9NUW8 2/20 0.39
MAPT P10636 2/20 0.39
TSHR P16473 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6214835 0.79 ALDH1A1 (0.49) ALDH1A1KDM4EHPGDPPARGPPARD
SCHEMBL16150885 0.77 ALDH1A1 (0.53) ALDH1A1KDM4EHPGDPPARGPPARD
SCHEMBL3333141 0.77 ERN1 (0.50) ALDH1A1KDM4EHPGDPPARGPPARD
SCHEMBL4984877 0.76 TLR2 (0.53) ALDH1A1KDM4EHPGDPPARGPPARD
SCHEMBL7387678 0.76 ALDH1A1 (0.49) ALDH1A1KDM4EHPGDPPARGPPARD
SCHEMBL30608694 0.76 ERN1 (0.55) ALDH1A1KDM4EHPGDERN1POLB
SCHEMBL27341820 0.75 ERN1 (0.45) ALDH1A1HPGDERN1TDP1TSHR
SCHEMBL27354250 0.75 ERN1 (0.45) ALDH1A1KDM4EHPGDERN1TDP1
SCHEMBL2845228 0.75 ALDH1A1 (0.53) ALDH1A1KDM4EHPGDPPARGPPARD
SCHEMBL13978664 0.73 ERN1 (0.50) ALDH1A1KDM4EHPGDPPARGPPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5593970-A ANTITUMOR AND ANTCARCINOGENIC AGENTS; TRETMENT OF CANCEROUS BONE MARROW BEFORE REGRAFTING BIOCHEM PHARMA INC. (CA) 1997-01-14 US disclosed
US-5348946-A Heteroanthracycline antitumor analogs BIOCHEM IMMUNOSYSTEMS, INC. (CA) 1994-09-20 US disclosed
EP-0533744-A1 HETEROCYCLIC ANTHRACYCLIONE AND ANTHRACYCLINE ANALOGS BIOCHEM PHARMA INC. (CA) 1993-03-31 EP disclosed
WO-1992015601-A2 HETEROANTHRACYCLINE ANTITUMOR ANALOGS BIOCHEM PHARMA, INC. (CA) 1992-09-17 WO disclosed
EP-0502661-A2 Heteroanthracycline anti-tumor analogues BIOCHEM PHARMA INC. (CA) 1992-09-09 EP disclosed
WO-1991019725-A2 HETEROCYCLIC ANTHRACYCLIONE AND ANTHRACYCLINE ANALOGS BIOCHEM PHARMA INC. (CA) 1991-12-26 WO disclosed