Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | PPARD | Q03181 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3333141 | 0.84 | ERN1 (0.50) | ALDH1A1KDM4EHPGDPPARGPPARD | |
| SCHEMBL8502169 | 0.83 | ALDH1A1 (0.45) | ALDH1A1KDM4EPOLBTUBB1CA1 | |
| SCHEMBL14112796 | 0.81 | CA1 (0.46) | ALDH1A1KDM4EPOLBTUBB1CA1 | |
| SCHEMBL13978664 | 0.81 | ERN1 (0.50) | ALDH1A1KDM4EHPGDPPARGPPARD | |
| SCHEMBL1162416 | 0.80 | KDM4E (0.42) | ALDH1A1KDM4EHPGDPPARGPPARD | |
| SCHEMBL6213995 | 0.80 | ALDH1A1 (0.43) | ALDH1A1KDM4EPOLBTUBB1CA1 | |
| SCHEMBL4984877 | 0.80 | TLR2 (0.53) | ALDH1A1KDM4EHPGDPPARGPPARD | |
| SCHEMBL8908376 | 0.79 | ALDH1A1 (0.51) | ALDH1A1KDM4EHPGDPPARGPPARD | |
| SCHEMBL1396838 | 0.78 | CA1 (0.50) | ALDH1A1HPGDPPARGCA1CA2 | |
| SCHEMBL31474876 | 0.76 | ALDH1A1 (0.56) | ALDH1A1KDM4EPOLBCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1256583-B1 | Pyrimidine-4-one derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2005-08-10 | — | — | EP | disclosed |
| US-6747032-B2 | DOUBLE ALPHA 2/5-HT 2C ANTAGONISTS USED TO TREAT DEPRESSION, IMPULSIVE BEHAVIOUR DISORDERS, ANXIETY, SCHIZOPHRENIA, PARKINSON'S DISEASE, COGNITIVE DISORDERS AND DISORDERS INVOLVING SEXUAL FUNCTION, SLEEP AND EATING | LES LABORATOIRES SERVIER (FR) | 2004-06-08 | — | — | US | disclosed |
| US-20030087916-A1 | Pyrimidin-4-one compounds | LES LABORATOIRES SERVIER (FR) | 2003-05-08 | — | — | US | disclosed |
| EP-1256583-A1 | Pyrimidine-4-one derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2002-11-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030087916-A1 | Pyrimidin-4-one compounds | HTR2C, HTR1A, HTR4 | ALDH1A1 1216/4885KDM4E 3635/4885HPGD 642/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.