SCHEMBL8908391

CC(C)C(NC(=O)C(Cc1ccccc1F)CC(O[Si](C)(C)C(C)(C)C)C(Cc1ccc(F)cc1)NC(=O)OC(C)(C)C)C(=O)NC(Cc1ccccc1)C(=O)NC(=O)N1CCOCC1

nearest known ligand 0.38

Predicted protein targets (top 15)

	gene	UniProt	supporting neighbours	confidence
▸	REN	P00797	2/20	0.37

▸	BACE1	P56817	8/20	0.37

▸	CTSS	P25774	3/20	0.36

▸	CTSK	P43235	2/20	0.36

▸	CASP3	P42574	1/20	0.36

▸	CTSD	P07339	1/20	0.36

▸	APP	P05067	1/20	0.36

▸	PSEN1	P49768	1/20	0.36

▸	PSEN2	P49810	1/20	0.36

▸	APH1B	Q8WW43	1/20	0.36

▸	NCSTN	Q92542	1/20	0.36

▸	APH1A	Q96BI3	1/20	0.36

▸	PSENEN	Q9NZ42	1/20	0.36

▸	KMT2A	Q03164	1/20	0.36

▸	SCN9A	Q15858	1/20	0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL8892626	0.98	REN (0.39)	RENBACE1CTSSCTSKCASP3
SCHEMBL7435623	0.95	PSEN1 (0.40)	RENBACE1CTSSCTSKCASP3
SCHEMBL7442606	0.95	PSEN1 (0.40)	RENBACE1CTSSCTSKCASP3
SCHEMBL8892199	0.94	REN (0.37)	RENBACE1CASP3CTSDAPP
SCHEMBL8892084	0.92	PSEN1 (0.38)	RENBACE1CTSSCTSKCASP3
SCHEMBL8892080	0.92	PSEN1 (0.38)	RENBACE1CTSSCTSKCASP3
SCHEMBL8893984	0.91	REN (0.39)	RENBACE1CTSSCASP3CTSD
SCHEMBL8892505	0.90	CTSD (0.41)	RENBACE1CTSSCTSKCTSD
SCHEMBL8892921	0.90	CTSS (0.41)	RENBACE1CTSSCTSKCASP3
SCHEMBL8894701	0.89	PSEN1 (0.39)	RENBACE1CTSSCASP3CTSD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-5643878-A	TREATMENT OF RETROVIRAL DISEASES LIKE AIDS	CIBA-GEIGY CORPORATION (US)	1997-07-01	—	—	US	disclosed