Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 5/20 | 0.36 |
| ▸ | TTR | P02766 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12907529 | 0.99 | TTR (0.38) | TTRGAAHTTMAPTKDM4E | |
| Bromide SCHEMBL4190244 | 0.92 | GAA (0.36) | TTRGAAHTTMAPTKDM4E | |
| SCHEMBL4192297 | 0.91 | GAA (0.37) | TTRGAAHTTMAPTKDM4E | |
| SCHEMBL17898189 | 0.87 | PPARA (0.45) | GAAHTTMAPTKDM4ETP53 | |
| SCHEMBL4192623 | 0.87 | ACHE (0.34) | TTRGAAHTTMAPTKDM4E | |
| SCHEMBL4178439 | 0.87 | MAPT (0.34) | TTRGAAHTTMAPTKDM4E | |
| SCHEMBL13979959 | 0.85 | SRC (0.32) | TTRGAAHTTMAPTKDM4E | |
| SCHEMBL13633608 | 0.84 | TTR (0.40) | TTRGAAHTTMAPTKDM4E | |
| SCHEMBL4197112 | 0.84 | TTR (0.40) | TTRGAAHTTMAPTKDM4E | |
| SCHEMBL13633604 | 0.84 | TTR (0.40) | TTRMAPTTP53ACHEPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5656500-A | LIPOSOMES COUPLED TO MOLECULES WITH BIOLOGICAL ACTIVITY SELECTED FROM ANTIGENS, ANTIBODIES, AND NUCLEIC ACIDS, THESE CONJUGATE ENCAPSULATE HYDROPHILIC POLYSUBSTITUTED ARYL ACRIDINIUM ESTERS | CHIRON DIAGNOSTICS CORPORATION (US) | 1997-08-12 | — | — | US | disclosed |
| US-5595875-A | DNA, RNA, IMMUNOASSAY, CHEMILUMINESCENCE | CIBA CORNING DIAGNOSTICS CORP. (US) | 1997-01-21 | — | — | US | disclosed |
| US-5449556-A | Chemiluminescent markers | CIBA CORNING DIAGNOSTICS CORP. (US) | 1995-09-12 | — | — | US | disclosed |
| US-5227489-A | Hydrophilic chemiluminescent markers | CIBA CORNING DIAGNOSTICS CORP. (US) | 1993-07-13 | — | — | US | disclosed |