SCHEMBL8909

SCHEMBL8909

FC(F)(F)c1ccc(Br)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 1/20 0.50
CA1 P00915 1/20 0.50
CA2 P00918 1/20 0.50
CA5A P35218 1/20 0.50
CA9 Q16790 1/20 0.50
ALDH1A1 P00352 1/20 0.50
TSHR P16473 1/20 0.50
CYP2A6 P11509 1/20 0.50
KIF11 P52732 5/20 0.48
CES2 O00748 1/20 0.46
CES1 P23141 1/20 0.46
ORAI1 Q96D31 1/20 0.46
ORAI2 Q96SN7 1/20 0.46
ORAI3 Q9BRQ5 1/20 0.46
TRPV6 Q9H1D0 1/20 0.46
MGLL Q99685 1/20 0.46
GSK3B P49841 2/20 0.43
PTPN1 P18031 1/20 0.43
AHR P35869 1/20 0.43
TAAR1 Q96RJ0 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1729090 0.97 TRPV1 (0.48) TRPV1CA1CA2CA5ACA9
SCHEMBL2841466 0.92 KIF11 (0.61) TRPV1CA1CA2CA5ACA9
SCHEMBL16626116 0.92 TRPV1 (0.46) TRPV1CA1CA2CA5ACA9
Bromobenzene SCHEMBL28432577 0.89 ALDH1A1 (0.62) TRPV1CA1CA2CA5ACA9
SCHEMBL25011793 0.85 TRPV1 (0.42) TRPV1CA1CA2CA5ACA9
SCHEMBL5982635 0.85 GLB1 (0.52) TRPV1CA1CA2CA5ACA9
Formic Acid SCHEMBL31514292 0.85 CES2 (0.46) TRPV1CA1CA2CA5ACA9
SCHEMBL9262733 0.85 SLC6A4 (0.53) TRPV1CA1CA2CA5ACA9
SCHEMBL8617788 0.85 KIF11 (0.47) TRPV1CA1CA2CA5ACA9
SCHEMBL27289737 0.85 CA1 (0.55) TRPV1CA1CA2CA5ACA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3824 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116874458-B Coumarin fluorescent probe based on benzotrifluoride derivative and application thereof 常州大学 2025-05-27 CN claimed
CN-119972144-A Method for preparing phenol or ether compound by photocatalysis 中国科学院化学研究所 2025-05-13 CN claimed
CN-119822916-A Chiral alpha-aryl alkyne compound and synthesis method thereof 同济大学 2025-04-15 CN claimed
CN-119775579-A Nickel-based metal organic framework, aniline compound and preparation methods of nickel-based metal organic framework and aniline compound 中国科学技术大学 2025-04-08 CN claimed
CN-118955262-A Direct cross-coupling method of pyridine ester and aryl bromide 南京工业大学 2024-11-15 CN claimed
CN-114835541-B Preparation method of chiral tetra-substituted bialkene acid compound based on palladium catalytic system 复旦大学 2024-09-24 CN claimed
CN-118652422-A High-purity high-temperature-resistant anti-aging low-dielectric polyphenyl ether and preparation method thereof 四川大学 2024-09-17 CN claimed
CN-116262728-B Pure organic room temperature phosphorescent material regulated and controlled through flexible chains, and preparation method and application thereof 武汉大学 2024-09-10 CN claimed
US-20240199521-A1 PREPARATION METHOD FOR TETRA-SUBSTITUTED ALLENOIC ACID COMPOUND BASED ON PALLADIUM CATALYTIC SYSTEM FUDAN UNIVERSITY (CN) 2024-06-20 US claimed
CN-117567387-A Method for preparing benzoxazine-4-ketone series compounds by using nitroaromatic hydrocarbon 南京德川医药科技有限公司 2024-02-20 CN claimed
WO-2004029363-A2 LOW VOC ASPHALT PRIMER BUILDING MATERIALS INVESTMENT CORPORATION (US) 2004-04-08 WO claimed
WO-2004024663-A1 METHOD FOR THE ORGANOMETALLIC PRODUCTION OF ORGANIC INTERMEDIATE PRODUCTS BY HALOGEN-METAL EXCHANGE REACTIONS CLARIANT GMBH (DE) 2004-03-25 WO claimed
WO-2003101966-A1 METHOD OF FORMING A CARBON-CARBON OR CARBON-HETEROATOM LINKAGE RHODIA CHIMIE (FR) 2003-12-11 WO claimed
WO-2003055894-A1 METHOD FOR THE PRODUCTION OF GRIGNARD COMPOUNDS Grünenthal GmbH (DE) 2003-07-10 WO claimed
CN-1374291-A Prepn of N,N-dialkyl substituted aniline JIANGSU PROV INST OF PESTICIDE (CN) 2002-10-16 CN claimed
EP-1003717-A1 PREPARATION AND USES OF HYDROCARBYLNITRONES ALBEMARLE CORPORATION (US) 2000-05-31 EP claimed
US-5998627-A Preparation and uses of hydrocarbylnitrones ALBEMARLE CORPORATION (US) 1999-12-07 US claimed
WO-1999006362-A1 PREPARATION AND USES OF HYDROCARBYLNITRONES ALBEMARLE CORPORATION (US) 1999-02-11 WO claimed
EP-0396250-A1 Pyrimidinone derivatives ZENECA LIMITED (GB) 1990-11-07 EP claimed
US-4940822-A Substituted benzenemethanol compounds, intermediates thereof, and preparation thereof WARNER-LAMBERT COMPANY (US) 1990-07-10 US claimed