Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 4/20 | 0.49 |
| ▸ | CA12 | O43570 | 3/20 | 0.49 |
| ▸ | CA1 | P00915 | 3/20 | 0.49 |
| ▸ | CA2 | P00918 | 3/20 | 0.49 |
| ▸ | CA5A | P35218 | 3/20 | 0.49 |
| ▸ | CA7 | P43166 | 3/20 | 0.49 |
| ▸ | CA9 | Q16790 | 3/20 | 0.49 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29034878 | 0.83 | TDP1 (0.73) | L3MBTL1TDP1PKMHTTCA4 | |
| SCHEMBL12230072 | 0.83 | ACHE (0.47) | L3MBTL1TDP1LMNAHCRTR1PKM | |
| SCHEMBL28101003 | 0.81 | TDP1 (0.70) | L3MBTL1TDP1LMNAPKMHTT | |
| SCHEMBL7619840 | 0.81 | LMNA (0.50) | L3MBTL1LMNAHCRTR1PKMHTT | |
| SCHEMBL561190 | 0.80 | L3MBTL1 (1.00) | L3MBTL1TDP1LMNAPKMHTT | |
| SCHEMBL29968685 | 0.79 | ACHE (0.50) | L3MBTL1LMNAHCRTR1CA1CA2 | |
| SCHEMBL8163505 | 0.79 | ACHE (0.50) | L3MBTL1LMNAHCRTR1CA1CA2 | |
| SCHEMBL28388783 | 0.79 | HCRTR1 (0.59) | L3MBTL1TDP1LMNAHCRTR1PKM | |
| SCHEMBL28834594 | 0.79 | L3MBTL1 (0.66) | L3MBTL1TDP1LMNAHTTCA4 | |
| SCHEMBL27988575 | 0.79 | TDP1 (0.66) | L3MBTL1TDP1LMNAHTTCA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5600015-A | USING RUTHENIUM COMPLEX OF OPTICALLY ACTIVE ATROPISOMERIC DIPHOSPHINE LIGAND AS HYDROGENATION CATALYST | HOFFMANN-LA ROCHE INC. (US) | 1997-02-04 | — | — | US | disclosed |
| EP-0565975-B1 | Process for the preparation of isoprenoid derivatives | HOFFMANN LA ROCHE (CH) | 1996-09-04 | — | — | EP | disclosed |
| EP-0530335-B1 | DIPHOSPHONIC ACID DERIVATES AS INTERMEDIATES FOR THE PRODUCTION OF DIPHOSPHINE LIGANDS | HOFFMANN LA ROCHE (CH) | 1996-08-14 | — | — | EP | disclosed |
| EP-0530336-B1 | CHIRAL PHOSPHINES | HOFFMANN LA ROCHE (CH) | 1996-03-06 | — | — | EP | disclosed |
| US-5302738-A | Chiral phosphines | HOFFMANN-LA ROCHE INC. (US) | 1994-04-12 | — | — | US | disclosed |
| US-5274125-A | Chirale phosphines | HOFFMANN-LA ROCHE INC. (US) | 1993-12-28 | — | — | US | disclosed |
| EP-0565975-A2 | Process for the preparation of isoprenoid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1993-10-20 | — | — | EP | disclosed |
| EP-0530335-A1 | DIPHOSPHONIC ACID DERIVATES AS INTERMEDIATES FOR THE PRODUCTION OF DIPHOSPHINE LIGANDS. | HOFFMANN LA ROCHE (CH) | 1993-03-10 | — | — | EP | disclosed |
| EP-0530336-A1 | CHIRAL PHOSPHINES. | HOFFMANN LA ROCHE (CH) | 1993-03-10 | — | — | EP | disclosed |
| WO-1992016536-A1 | CHIRAL PHOSPHINES | F. HOFFMANN-LA ROCHE AG (CH) | 1992-10-01 | — | — | WO | disclosed |
| WO-1992016535-A1 | DIPHOSPHONIC ACID DERIVATES AS INTERMEDIATES FOR THE PRODUCTION OF DIPHOSPHINE LIGANDS | F.HOFFMANN-LA ROCHE AG (CH) | 1992-10-01 | — | — | WO | disclosed |