Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.51 |
| ▸ | AGXT | P21549 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 3/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14075637 | 0.80 | LOXL2 (0.69) | LOXL2AGXTADRA2AHTR2BHTR1A | |
| SCHEMBL4612712 | 0.78 | CYP11B1 (0.56) | CYP19A1SMN1; SMN2KDM4E | |
| SCHEMBL6427450 | 0.73 | TAAR1 (0.54) | LOXL2AGXTADRA2AHTR2BHTR1A | |
| SCHEMBL7806512 | 0.73 | LOXL2 (0.60) | LOXL2AGXTHTR2BHTR1ACYP19A1 | |
| Dimethylamine SCHEMBL25351475 | 0.72 | LOXL2 (0.58) | LOXL2AGXTADRA2AHTR2BHTR1A | |
| SCHEMBL26445730 | 0.69 | LOXL2 (0.55) | LOXL2AGXTHTR2BHTR1ASLC5A2 | |
| SCHEMBL11107879 | 0.69 | LOXL2 (0.55) | LOXL2AGXTHTR2BHTR1ASMN1; SMN2 | |
| SCHEMBL920529 | 0.69 | LOXL2 (0.50) | LOXL2AGXTADRA2AHTR2BHTR1A | |
| SCHEMBL1680581 | 0.69 | LOXL2 (0.50) | LOXL2AGXTADRA2AHTR2BHTR1A | |
| SCHEMBL118929 | 0.69 | LOXL2 (0.64) | LOXL2AGXTADRA2AHTR2BHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5679694-A | LOW TOXICITY AGAINST NORMAL CELL LINES | THE WELLCOME FOUNDATION LTD. (GB) | 1997-10-21 | — | — | US | disclosed |
| EP-0651750-A1 | TETRACYCLIC COMPOUNDS PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOUR AGENTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-05-10 | — | — | EP | disclosed |
| WO-1994002483-A1 | TETRACYCLIC COMPOUNDS PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOUR AGENTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-02-03 | — | — | WO | disclosed |