Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 11/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8910605 | 0.82 | SIGMAR1 (0.60) | SIGMAR1HIF1AHSD11B1 | |
| SCHEMBL8908767 | 0.78 | SIGMAR1 (0.46) | SIGMAR1HIF1AHSD11B1 | |
| SCHEMBL8909799 | 0.77 | SIGMAR1 (0.43) | SIGMAR1HIF1A | |
| SCHEMBL8105933 | 0.76 | SIGMAR1 (0.56) | SIGMAR1ALDH1A1KDM4EHSD17B10HIF1A | |
| SCHEMBL8105937 | 0.76 | SIGMAR1 (0.56) | SIGMAR1ALDH1A1KDM4EHSD17B10HIF1A | |
| SCHEMBL8908632 | 0.76 | SIGMAR1 (0.56) | SIGMAR1ALDH1A1KDM4EHSD17B10HIF1A | |
| SCHEMBL8909904 | 0.73 | SIGMAR1 (0.68) | SIGMAR1HIF1A | |
| SCHEMBL8910607 | 0.73 | BPTF (0.49) | SIGMAR1ALDH1A1HIF1AHSD11B1 | |
| SCHEMBL8909808 | 0.73 | SIGMAR1 (0.53) | SIGMAR1HIF1AHSD11B1 | |
| SCHEMBL8910246 | 0.72 | SIGMAR1 (0.43) | SIGMAR1HIF1AHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5658923-A | USED IN TREATING DISEASES RELATED TO SIGMA-RECEPTOR, SUCH AS SCHIZOPHRENIA | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1997-08-19 | — | — | US | disclosed |