Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 11/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8908632 | 1.00 | SIGMAR1 (0.56) | SIGMAR1OPRM1OPRL1NAMPTHIF1A | |
| SCHEMBL8105937 | 1.00 | SIGMAR1 (0.56) | SIGMAR1OPRM1OPRL1NAMPTHIF1A | |
| SCHEMBL8099508 | 0.86 | SIGMAR1 (0.58) | SIGMAR1ALDH1A1 | |
| SCHEMBL8909799 | 0.82 | SIGMAR1 (0.43) | SIGMAR1OPRM1OPRL1HIF1A | |
| SCHEMBL8910605 | 0.77 | SIGMAR1 (0.60) | SIGMAR1HIF1A | |
| SCHEMBL5499445 | 0.76 | SIGMAR1 (0.47) | SIGMAR1HIF1AKDM4E | |
| SCHEMBL8909813 | 0.76 | SIGMAR1 (0.45) | SIGMAR1HIF1AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL8909815 | 0.73 | SIGMAR1 (0.40) | SIGMAR1HIF1A | |
| SCHEMBL8910607 | 0.73 | BPTF (0.49) | SIGMAR1HIF1AALDH1A1 | |
| SCHEMBL8908767 | 0.73 | SIGMAR1 (0.46) | SIGMAR1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0661271-B1 | AZEPINE DERIVATIVES, PRODUCTION THEREOF, AND USE THEREOF AS SIGMA-RECEPTOR LIGANDS | ASAHI CHEMICAL IND (JP) | 2000-04-26 | — | — | EP | disclosed |
| EP-0661271-A1 | AZEPINE DERIVATIVE, PRODUCTION THEREOF, AND USE THEREOF | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1995-07-05 | — | — | EP | disclosed |