Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR17 | Q13304 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.55 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.55 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.55 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.55 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.55 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.55 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.55 |
| ▸ | MAP2 | P11137 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6921821 | 0.86 | MAP2 (0.65) | GPR17KDM4EMEN1LMNAKMT2A | |
| SCHEMBL1144990 | 0.84 | GPR17 (0.60) | GPR17KDM4EMEN1LMNACYP2C9 | |
| SCHEMBL9449344 | 0.84 | GPR17 (0.60) | GPR17KDM4EMEN1LMNACYP2C9 | |
| SCHEMBL8752546 | 0.83 | GPR17 (0.58) | GPR17KDM4EMEN1LMNACYP2C9 | |
| SCHEMBL27784165 | 0.83 | GPR17 (0.47) | GPR17KDM4EMEN1LMNAHPGD | |
| SCHEMBL4333071 | 0.83 | GPR17 (0.58) | GPR17KDM4EMEN1LMNACYP2C9 | |
| SCHEMBL21341417 | 0.83 | GPR17 (0.58) | GPR17MEN1CYP2C9KMT2A | |
| SCHEMBL31025926 | 0.80 | GPR17 (0.72) | GPR17 | |
| SCHEMBL31025899 | 0.80 | ALOX15 (0.65) | GPR17KDM4EMEN1LMNACYP2C9 | |
| SCHEMBL9187231 | 0.79 | GPR17 (0.74) | GPR17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5688946-A | DIPEPTIDES FOR HYPOTENSIVE AGENTS AND CARDIOVASCULAR DISORDERS | HOFFMANN LA ROCHE INC. (US) | 1997-11-18 | — | — | US | disclosed |
| EP-0416373-A2 | Amino acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1991-03-13 | — | — | EP | disclosed |