Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | CHAT | P28329 | 2/20 | 0.45 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | PAM | P19021 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | BCHE | P06276 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7994352 | 0.98 | RAB9A (0.47) | CHRNA7RAB9ACHATIDO1PAM | |
| SCHEMBL7994346 | 0.98 | RAB9A (0.47) | CHRNA7RAB9ACHATIDO1PAM | |
| Iodide SCHEMBL23888749 | 0.81 | RELA (0.53) | RAB9AINSRNPC1L3MBTL1 | |
| Iodide SCHEMBL23888751 | 0.81 | RELA (0.53) | RAB9AINSRNPC1L3MBTL1 | |
| SCHEMBL9003935 | 0.78 | LCK (0.50) | — | |
| SCHEMBL9777486 | 0.71 | IDO1 (0.58) | RAB9AIDO1PAMHTR2AMAOB | |
| SCHEMBL4863423 | 0.71 | IDO1 (0.58) | RAB9AIDO1PAMHTR2AMAOB | |
| SCHEMBL3927955 | 0.70 | IDO1 (0.52) | RAB9AIDO1PAMHTR2AMAOB | |
| SCHEMBL2541656 | 0.70 | IDO1 (0.52) | RAB9AIDO1PAMHTR2AMAOB | |
| SCHEMBL7939387 | 0.69 | IDO1 (0.56) | RAB9AIDO1PAMHTR2AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0670041-A4 | FLUORESCENCE ENERGY TRANSFER AND INTRAMOLECULAR ENERGY TRANSFER IN PARTICLES USING NOVEL COMPOUNDS. | BIOSITE DIAGNOSTICS INC (US) | 1997-11-05 | — | — | EP | disclosed |
| EP-0670041-A1 | FLUORESCENCE ENERGY TRANSFER AND INTRAMOLECULAR ENERGY TRANSFER IN PARTICLES USING NOVEL COMPOUNDS | BIOSITE DIAGNOSTICS INC. (US) | 1995-09-06 | — | — | EP | disclosed |
| WO-1995008772-A1 | FLUORESCENCE ENERGY TRANSFER AND INTRAMOLECULAR ENERGY TRANSFER IN PARTICLES USING NOVEL COMPOUNDS | BIOSITE DIAGNOSTICS INCORPORATED (US) | 1995-03-30 | — | — | WO | disclosed |